Possible role of endogenous ouabain-like compounds in the pathophysiology of bipolar Illness

Paul Christo, R. S. El-Mallakh

Research output: Contribution to journalArticle

Abstract

A large number of studies have documented a mood-state-related decrease in blood cell sodium, potassium-activated adenosine triphosphatase (Na, K-ATPase) activity in acutely ill bipolar patients. While it has been proposed that this enzymatic change may be central to the pathophysiology of bipolar illness, its genesis has remained obscure. Recent advances in the isolation and characterization of endogenously produced ouabain- or digoxin-like compounds suggest a possible mechanism by which these mood-state-related changes can come about. We herein propose that the hypothalamic-pituitary-adrenal dysregulation frequently documented in major mood disorders may underlie a pathological increase in the production of endogenous ouabain-like compounds which excessively suppresses Na, K-ATPase activity and results in pathological mood and energy alteration.

Original languageEnglish (US)
Pages (from-to)378-383
Number of pages6
JournalMedical Hypotheses
Volume41
Issue number4
DOIs
StatePublished - 1993
Externally publishedYes

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Ouabain
Sodium-Potassium-Exchanging ATPase
Digoxin
Mood Disorders
Blood Cells
sodium-translocating ATPase

ASJC Scopus subject areas

  • Developmental Biology
  • Medicine(all)
  • Drug Discovery

Cite this

Possible role of endogenous ouabain-like compounds in the pathophysiology of bipolar Illness. / Christo, Paul; El-Mallakh, R. S.

In: Medical Hypotheses, Vol. 41, No. 4, 1993, p. 378-383.

Research output: Contribution to journalArticle

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