Possible role of endogenous ouabain-like compounds in the pathophysiology of bipolar Illness

P. J. Christo, R. S. El-Mallakh

Research output: Contribution to journalArticle

Abstract

A large number of studies have documented a mood-state-related decrease in blood cell sodium, potassium-activated adenosine triphosphatase (Na, K-ATPase) activity in acutely ill bipolar patients. While it has been proposed that this enzymatic change may be central to the pathophysiology of bipolar illness, its genesis has remained obscure. Recent advances in the isolation and characterization of endogenously produced ouabain- or digoxin-like compounds suggest a possible mechanism by which these mood-state-related changes can come about. We herein propose that the hypothalamic-pituitary-adrenal dysregulation frequently documented in major mood disorders may underlie a pathological increase in the production of endogenous ouabain-like compounds which excessively suppresses Na, K-ATPase activity and results in pathological mood and energy alteration.

Original languageEnglish (US)
Pages (from-to)378-383
Number of pages6
JournalMedical Hypotheses
Volume41
Issue number4
DOIs
StatePublished - Oct 1993
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Possible role of endogenous ouabain-like compounds in the pathophysiology of bipolar Illness'. Together they form a unique fingerprint.

  • Cite this