Abstract
In the present study, in vitro radiation survival analysis was performed on 8 human malignant melanoma cell lines with defined karyotypes. Exponentially growing cells were irradiated to doses of 0 to 8 Gy and examined for soft agar clonogenicity. Two groups emerged from this analysis: 4 cell lines with a small shoulder (extrapolation number, n < 2) and 4 cell lines with a large shoulder (n > 2). Of possible significance, 4 4 cell lines with extrapolation numbers > 2 demonstrated clonal structural abnormalities of chromosome 7. In contrast, 3 4 cell lines with extrapolation numbers < 2 had no structural abnormalities of chromosome 7. These very preliminary results suggest that structural alterations of chromosome 7 may be associated with melanoma tumors with high extrapolation numbers.
Original language | English (US) |
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Pages (from-to) | 349-355 |
Number of pages | 7 |
Journal | International journal of radiation oncology, biology, physics |
Volume | 19 |
Issue number | 2 |
DOIs | |
State | Published - Aug 1990 |
Externally published | Yes |
Keywords
- Cytogenetics
- Malignant melanoma
- Radiosensitivity
ASJC Scopus subject areas
- Radiation
- Oncology
- Radiology Nuclear Medicine and imaging
- Cancer Research