Possible molecular mechanisms involved in the toxicity of angiogenesis inhibition

Henk M W Verheul, Herbert M. Pinedo

Research output: Contribution to journalArticlepeer-review

Abstract

Contrary to initial expectations, angiogenesis inhibitors can cause toxicities in patients with cancer. The toxicity profiles of these inhibitors reflect the disturbance of growth factor signalling pathways that are important for maintaining homeostasis. Experiences with angiogenesis inhibitors in clinical trials indicate that short-term toxicities are mostly manageable. However, these agents will also be given in prolonged treatment strategies, so we need to anticipate possible long-term toxicities. In addition, understanding the molecular mechanisms involved in the toxicity of angiogenesis inhibition should allow more specific and more potent inhibitors to be developed.

Original languageEnglish (US)
Pages (from-to)475-485
Number of pages11
JournalNature Reviews Cancer
Volume7
Issue number6
DOIs
StatePublished - Jun 2007
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research

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