Possible linkage of alcoholism, monoamine oxidase activity and P300 amplitude to markers on chromosome 12q24

Suh Hang Hank Juo, Elizabeth W. Pugh, Agnes Baffoe-Bonnie, Albert Kingman, Alexa J.M. Sorant, Alison P. Klein, Jennifer O'Neill, Rasika A. Mathias, Alexander F. Wilson, Joan E. Bailey-Wilson

Research output: Contribution to journalArticlepeer-review

Abstract

Multipoint linkage analysis was used to screen for evidence of linkage between alcoholism and five alcoholism-related quantitative traits. The results suggest that a susceptibility locus that influences monoamine oxidase activity and P300 amplitude at the Pz lead, and increases the risk of alcohol dependence may be linked to markers in the 12q24 region. Furthermore, the susceptibility for alcoholism may be associated with allele 3 (allele size 144) of D12S392.

Original languageEnglish (US)
Pages (from-to)S193-S198
JournalGenetic epidemiology
Volume17
Issue numberSUPPL. 1
DOIs
StatePublished - 1999

Keywords

  • Association
  • Genetics
  • MAO

ASJC Scopus subject areas

  • Epidemiology
  • Genetics(clinical)

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