Abstract
Introduction. The drugs gabapentin and ketamine are used frequently in the peri-operative setting. There is poor documentation whether or not gabapentin and ketamine interact to cause prolonged depression of the central nervous system. Case Presentation. The following is a case report in which a patient, a 58-year-old African-American man, with a history of post-traumatic stress disorder and chronic pain underwent a cervical laminoplasty procedure. The patient presented post-operatively in a dissociative state with paralysis, anarthria and preservation of consciousness. All organic causes were excluded, with the exception of prolonged central nervous system depression from a gabapentin/ketamine drug interaction. A new onset conversion disorder could also not be excluded. Conclusion: Although this case by itself is not enough evidence to substantiate a true adverse reaction between gabapentin and ketamine, it is enough to warrant further investigation.
| Original language | English (US) |
|---|---|
| Article number | 167 |
| Journal | Journal of Medical Case Reports |
| Volume | 5 |
| DOIs | |
| State | Published - May 2 2011 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Possible gabapentin and ketamine interaction causing prolonged central nervous system depression during post-operative recovery following cervical laminoplasty : A case report. / Elyassi, Ali R.; Long, Robert P.; Bejnarowicz, Robert P.; Schoneboom, Bruce.
In: Journal of Medical Case Reports, Vol. 5, 167, 02.05.2011.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Possible gabapentin and ketamine interaction causing prolonged central nervous system depression during post-operative recovery following cervical laminoplasty
T2 - A case report
AU - Elyassi, Ali R.
AU - Long, Robert P.
AU - Bejnarowicz, Robert P.
AU - Schoneboom, Bruce
PY - 2011/5/2
Y1 - 2011/5/2
N2 - Introduction. The drugs gabapentin and ketamine are used frequently in the peri-operative setting. There is poor documentation whether or not gabapentin and ketamine interact to cause prolonged depression of the central nervous system. Case Presentation. The following is a case report in which a patient, a 58-year-old African-American man, with a history of post-traumatic stress disorder and chronic pain underwent a cervical laminoplasty procedure. The patient presented post-operatively in a dissociative state with paralysis, anarthria and preservation of consciousness. All organic causes were excluded, with the exception of prolonged central nervous system depression from a gabapentin/ketamine drug interaction. A new onset conversion disorder could also not be excluded. Conclusion: Although this case by itself is not enough evidence to substantiate a true adverse reaction between gabapentin and ketamine, it is enough to warrant further investigation.
AB - Introduction. The drugs gabapentin and ketamine are used frequently in the peri-operative setting. There is poor documentation whether or not gabapentin and ketamine interact to cause prolonged depression of the central nervous system. Case Presentation. The following is a case report in which a patient, a 58-year-old African-American man, with a history of post-traumatic stress disorder and chronic pain underwent a cervical laminoplasty procedure. The patient presented post-operatively in a dissociative state with paralysis, anarthria and preservation of consciousness. All organic causes were excluded, with the exception of prolonged central nervous system depression from a gabapentin/ketamine drug interaction. A new onset conversion disorder could also not be excluded. Conclusion: Although this case by itself is not enough evidence to substantiate a true adverse reaction between gabapentin and ketamine, it is enough to warrant further investigation.
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U2 - 10.1186/1752-1947-5-167
DO - 10.1186/1752-1947-5-167
M3 - Article
C2 - 21527000
AN - SCOPUS:79955136521
VL - 5
JO - Journal of Medical Case Reports
JF - Journal of Medical Case Reports
SN - 1752-1947
M1 - 167
ER -