Possible association of the MAG locus with schizophrenia in a Chinese Han cohort of family trios

Y. F. Yang, W. Qin, Y. Y. Shugart, G. He, X. M. Liu, J. Zhou, X. Z. Zhao, Q. Chen, Y. J. La, Y. F. Xu, X. W. Li, N. F. Gu, G. Y. Feng, H. Song, P. Wang, L. He

Research output: Contribution to journalArticle

Abstract

Neurotransmitter-based hypotheses have so far led to only moderate success in predicting new pathogenetic findings in etiology of schizophrenia. On the other hand, the more recent oligodendroglia hypotheses of this disorder have been supported by an increasing body of evidence. For example, the expression level of the myelin associated glycopretein (MAG) gene has been shown to be significantly lower in schizophrenia patient groups compared to control groups. Such an effect might be a result of genetic variations of the MAG gene. In order to test this hypothesis, we genotyped four markers within the MAG locus in 413 trios sample of the Han Chinese using allele-specific PCR. None of the four markers revealed noticeable allelic significance. However, the four-marker and two-marker haplotypes covering components rs720309 and rs720308 were observed to be significantly associated with schizophrenia (P

Original languageEnglish (US)
Pages (from-to)11-19
Number of pages9
JournalSchizophrenia Research
Volume75
Issue number1
DOIs
StatePublished - Jun 1 2005

Keywords

  • Association
  • Haplotype
  • Myelin-associated glycoprotein
  • Oligodendroglia
  • Schizophrenia
  • TDT

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Neurology
  • Psychology(all)

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    Yang, Y. F., Qin, W., Shugart, Y. Y., He, G., Liu, X. M., Zhou, J., Zhao, X. Z., Chen, Q., La, Y. J., Xu, Y. F., Li, X. W., Gu, N. F., Feng, G. Y., Song, H., Wang, P., & He, L. (2005). Possible association of the MAG locus with schizophrenia in a Chinese Han cohort of family trios. Schizophrenia Research, 75(1), 11-19. https://doi.org/10.1016/j.schres.2004.11.013