Possible association between genetic variants at the GRIN1 gene and schizophrenia with lifetime history of depressive symptoms in a German sample

Alexander Georgi; Rami Abou Jamra; Katrin Klein; Angela Wolf Villela; Johannes Schumacher; Tim Becker; Torsten Paul; Christine Schmael; Susanne Höfels; Norman Klopp; Thomas Illig; Peter Propping; Sven Cichon; Markus M. Nöthen; Thomas G. Schulze; Marcella Rietschel

doi:10.1097/YPG.0b013e3280c1e5fb

Possible association between genetic variants at the GRIN1 gene and schizophrenia with lifetime history of depressive symptoms in a German sample

Alexander Georgi, Rami Abou Jamra, Katrin Klein, Angela Wolf Villela, Johannes Schumacher, Tim Becker, Torsten Paul, Christine Schmael, Susanne Höfels, Norman Klopp, Thomas Illig, Peter Propping, Sven Cichon, Markus M. Nöthen, Thomas G. Schulze, Marcella Rietschel

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28 Scopus citations

Abstract

Genetic variation in glutamatergic signalling pathways is believed to play a substantial role in the aetiology of schizophrenia. The N-methyl-D-aspartate receptor subunit gene GRIN1 has been proposed as a candidate gene for schizophrenia. We tested for a potential association between schizophrenia and four single nucleotide polymorphisms (rs4880213, rs11146020, rs6293, and rs10747050) and one microsatellite marker at GRIN1 in a German sample of 354 patients and 323 controls. We found significant associations in single-marker and haplotype-based analyses (P

Original language	English (US)
Pages (from-to)	308-310
Number of pages	3
Journal	Psychiatric Genetics
Volume	17
Issue number	5
DOIs	https://doi.org/10.1097/YPG.0b013e3280c1e5fb
State	Published - Oct 2007
Externally published	Yes

Keywords

Affective disorder
Depression
Genotype-phenotype correlation
Glutamate
N-methyl-D-aspartate
Psychosis

ASJC Scopus subject areas

Genetics(clinical)
Psychiatry and Mental health
Genetics
General Neuroscience

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10.1097/YPG.0b013e3280c1e5fb

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Georgi, A., Jamra, R. A., Klein, K., Villela, A. W., Schumacher, J., Becker, T., Paul, T., Schmael, C., Höfels, S., Klopp, N., Illig, T., Propping, P., Cichon, S., Nöthen, M. M., Schulze, T. G., & Rietschel, M. (2007). Possible association between genetic variants at the GRIN1 gene and schizophrenia with lifetime history of depressive symptoms in a German sample. Psychiatric Genetics, 17(5), 308-310. https://doi.org/10.1097/YPG.0b013e3280c1e5fb

Georgi, A, Jamra, RA, Klein, K, Villela, AW, Schumacher, J, Becker, T, Paul, T, Schmael, C, Höfels, S, Klopp, N, Illig, T, Propping, P, Cichon, S, Nöthen, MM, Schulze, TG & Rietschel, M 2007, 'Possible association between genetic variants at the GRIN1 gene and schizophrenia with lifetime history of depressive symptoms in a German sample', Psychiatric Genetics, vol. 17, no. 5, pp. 308-310. https://doi.org/10.1097/YPG.0b013e3280c1e5fb

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abstract = "Genetic variation in glutamatergic signalling pathways is believed to play a substantial role in the aetiology of schizophrenia. The N-methyl-D-aspartate receptor subunit gene GRIN1 has been proposed as a candidate gene for schizophrenia. We tested for a potential association between schizophrenia and four single nucleotide polymorphisms (rs4880213, rs11146020, rs6293, and rs10747050) and one microsatellite marker at GRIN1 in a German sample of 354 patients and 323 controls. We found significant associations in single-marker and haplotype-based analyses (P",

keywords = "Affective disorder, Depression, Genotype-phenotype correlation, Glutamate, N-methyl-D-aspartate, Psychosis",

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AU - Jamra, Rami Abou

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AU - Villela, Angela Wolf

AU - Schumacher, Johannes

AU - Becker, Tim

AU - Paul, Torsten

AU - Schmael, Christine

AU - Höfels, Susanne

AU - Klopp, Norman

AU - Illig, Thomas

AU - Propping, Peter

AU - Cichon, Sven

AU - Nöthen, Markus M.

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Possible association between genetic variants at the GRIN1 gene and schizophrenia with lifetime history of depressive symptoms in a German sample

Abstract

Keywords

ASJC Scopus subject areas

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