Possible association between genetic variants at the GRIN1 gene and schizophrenia with lifetime history of depressive symptoms in a German sample

Alexander Georgi, Rami Abou Jamra, Katrin Klein, Angela Wolf Villela, Johannes Schumacher, Tim Becker, Torsten Paul, Christine Schmael, Susanne Höfels, Norman Klopp, Thomas Illig, Peter Propping, Sven Cichon, Markus M. Nöthen, Thomas G. Schulze, Marcella Rietschel

Research output: Contribution to journalArticle

Abstract

Genetic variation in glutamatergic signalling pathways is believed to play a substantial role in the aetiology of schizophrenia. The N-methyl-D-aspartate receptor subunit gene GRIN1 has been proposed as a candidate gene for schizophrenia. We tested for a potential association between schizophrenia and four single nucleotide polymorphisms (rs4880213, rs11146020, rs6293, and rs10747050) and one microsatellite marker at GRIN1 in a German sample of 354 patients and 323 controls. We found significant associations in single-marker and haplotype-based analyses (P

Original languageEnglish (US)
Pages (from-to)308-310
Number of pages3
JournalPsychiatric Genetics
Volume17
Issue number5
DOIs
StatePublished - Oct 2007
Externally publishedYes

Keywords

  • Affective disorder
  • Depression
  • Genotype-phenotype correlation
  • Glutamate
  • N-methyl-D-aspartate
  • Psychosis

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Genetics
  • Neuroscience(all)

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    Georgi, A., Jamra, R. A., Klein, K., Villela, A. W., Schumacher, J., Becker, T., Paul, T., Schmael, C., Höfels, S., Klopp, N., Illig, T., Propping, P., Cichon, S., Nöthen, M. M., Schulze, T. G., & Rietschel, M. (2007). Possible association between genetic variants at the GRIN1 gene and schizophrenia with lifetime history of depressive symptoms in a German sample. Psychiatric Genetics, 17(5), 308-310. https://doi.org/10.1097/YPG.0b013e3280c1e5fb