Positron emission tomography study of a chronic pain patient successfully treated with somatosensory thalamic stimulation

Ron C. Kupers, Jan M. Gybels, Albert Gjedde

Research output: Contribution to journalArticle

Abstract

Previous neuroimaging studies suggested that the neuronal network underlying the perception of chronic pain may differ from that underlying acute pain. To further map the neural network associated with chronic pain, we used positron emission tomography (PET) to determine significant regional cerebral blood flow (rCBF) changes in a patient with chronic facial pain. The patient is implanted with a chronic stimulation electrode in the left ventroposterior medial thalamic nucleus with which he can completely suppress his chronic pain. The patient was scanned in the following conditions: before thalamic stimulation (pain, no stimulation), during thalamic stimulation (no pain, stimulation) and after successful thalamic stimulation (no pain, no stimulation). Comparing baseline scans during pain with scans taken after stimulation, when the patient had become pain-free, revealed significant rCBF increases in the prefrontal (Brodmann areas (BA) 9, 10, 11 and 47) and anterior insular cortices, hypothalamus and periaqueductal gray associated with the presence of chronic pain. No significant rCBF changes occurred in thalamus, primary and secondary somatosensory cortex and anterior cingulate cortex, BA 24'. Significant rCBF decreases were observed in the substantia nigra/nucleus ruber and in the anterior pulvinar nucleus. During thalamic stimulation, blood flow significantly increased in the amygdala and anterior insular cortex. These data further support that there are important differences in the cerebral processing of acute and chronic pain. (C) 2000 International Association for the Study of Pain.

Original languageEnglish (US)
Pages (from-to)295-302
Number of pages8
JournalPain
Volume87
Issue number3
DOIs
StatePublished - Aug 1 2000
Externally publishedYes

Fingerprint

Cerebrovascular Circulation
Chronic Pain
Positron-Emission Tomography
Regional Blood Flow
Pain
Somatosensory Cortex
Acute Pain
Cerebral Cortex
Pulvinar
Red Nucleus
Mediodorsal Thalamic Nucleus
Periaqueductal Gray
Facial Pain
Gyrus Cinguli
Substantia Nigra
Amygdala
Thalamus
Neuroimaging
Hypothalamus
Electrodes

Keywords

  • Amygdala
  • Analgesia
  • Anterior insula
  • Deep brain stimulation
  • Neuropathic pain
  • Positron emission tomography
  • Prefrontal cortex

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Neurology
  • Neuroscience(all)
  • Pharmacology
  • Clinical Psychology

Cite this

Positron emission tomography study of a chronic pain patient successfully treated with somatosensory thalamic stimulation. / Kupers, Ron C.; Gybels, Jan M.; Gjedde, Albert.

In: Pain, Vol. 87, No. 3, 01.08.2000, p. 295-302.

Research output: Contribution to journalArticle

Kupers, Ron C. ; Gybels, Jan M. ; Gjedde, Albert. / Positron emission tomography study of a chronic pain patient successfully treated with somatosensory thalamic stimulation. In: Pain. 2000 ; Vol. 87, No. 3. pp. 295-302.
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