Positron emission tomography radioligands for the opioid system

Research output: Contribution to journalReview articlepeer-review

Abstract

Opiate receptors are found in the brain, the spinal cord, some peripheral sensory neurons, and the gastrointestinal tract. Naturally occurring and synthetic opiate ligands exert their influence on a wide variety of processes including analgesia, euphoria, dysphoria, sedation, respiratory depression, and miosis and are frequently topics for discussions on addiction and physical dependence. This review looks at the history of positron emission tomography radioligands for probing this receptor system.

Original languageEnglish (US)
Pages (from-to)187-195
Number of pages9
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume56
Issue number3-4
DOIs
StatePublished - Mar 1 2013

Keywords

  • fluorine-18
  • neuroreceptor
  • opiate
  • receptor

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Drug Discovery
  • Spectroscopy
  • Organic Chemistry

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