Positron emission tomography-measured abnormal responses of myocardial blood flow to sympathetic stimulation are associated with the risk of developing cardiovascular events

Thomas H. Schindler, Egbert U. Nitzsche, Heinrich R. Schelbert, Manfred Olschewski, James Sayre, Michael Mix, Ingo Brink, Xiao Li Zhang, Michael Kreissl, Nobuhisa Magosaki, Hanjoerg Just, Ulrich Solzbach

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: We sought to assess prospectively whether patients with normal coronary angiograms but with impaired myocardial blood flow (MBF) increases to cold pressor testing (CPT) are at increased risk for cardiovascular events. BACKGROUND: Invasive angiographic assessments of coronary vasomotor function have demonstrated an impairment of endothelium-related coronary flow increases to independently predict future cardiovascular events. It is unknown whether noninvasive positron emission tomography (PET)-measured MBF alterations to sympathetic stimulation with CPT are associated with the risk of developing cardiovascular events. METHODS: A total of 72 patients (44 men, 28 women, age 58 ± 8 years) referred for diagnostic cardiac catheterization were studied. Myocardial blood flow was measured in absolute units with 13N- ammonia using PET, at baseline and during CPT in each patient. Cardiovascular events (cardiovascular death, acute coronary syndrome, myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, ischemic stroke, or peripheral revascularization) were assessed as clinical outcome parameters over a mean follow-up period of 66 ± 8 months. Patients were assigned to three groups: group 1, patients with 0 and

Original languageEnglish (US)
Pages (from-to)1505-1512
Number of pages8
JournalJournal of the American College of Cardiology
Volume45
Issue number9
DOIs
StatePublished - May 3 2005
Externally publishedYes

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Positron-Emission Tomography
Coronary Balloon Angioplasty
Acute Coronary Syndrome
Cardiac Catheterization
Ammonia
Coronary Artery Bypass
Endothelium
Angiography
Stroke
Myocardial Infarction

ASJC Scopus subject areas

  • Nursing(all)

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Positron emission tomography-measured abnormal responses of myocardial blood flow to sympathetic stimulation are associated with the risk of developing cardiovascular events. / Schindler, Thomas H.; Nitzsche, Egbert U.; Schelbert, Heinrich R.; Olschewski, Manfred; Sayre, James; Mix, Michael; Brink, Ingo; Zhang, Xiao Li; Kreissl, Michael; Magosaki, Nobuhisa; Just, Hanjoerg; Solzbach, Ulrich.

In: Journal of the American College of Cardiology, Vol. 45, No. 9, 03.05.2005, p. 1505-1512.

Research output: Contribution to journalArticle

Schindler, TH, Nitzsche, EU, Schelbert, HR, Olschewski, M, Sayre, J, Mix, M, Brink, I, Zhang, XL, Kreissl, M, Magosaki, N, Just, H & Solzbach, U 2005, 'Positron emission tomography-measured abnormal responses of myocardial blood flow to sympathetic stimulation are associated with the risk of developing cardiovascular events', Journal of the American College of Cardiology, vol. 45, no. 9, pp. 1505-1512. https://doi.org/10.1016/j.jacc.2005.01.040
Schindler, Thomas H. ; Nitzsche, Egbert U. ; Schelbert, Heinrich R. ; Olschewski, Manfred ; Sayre, James ; Mix, Michael ; Brink, Ingo ; Zhang, Xiao Li ; Kreissl, Michael ; Magosaki, Nobuhisa ; Just, Hanjoerg ; Solzbach, Ulrich. / Positron emission tomography-measured abnormal responses of myocardial blood flow to sympathetic stimulation are associated with the risk of developing cardiovascular events. In: Journal of the American College of Cardiology. 2005 ; Vol. 45, No. 9. pp. 1505-1512.
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AU - Zhang, Xiao Li

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AU - Just, Hanjoerg

AU - Solzbach, Ulrich

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