Positron emission tomography in the detection and management of sarcomatous transformation in neurofibromatosis

Stephen B. Solomon, A. Semih Dogan, Theresa L. Nicol, James N. Campbell, Martin G. Pomper

Research output: Contribution to journalArticlepeer-review

Abstract

Benign neurofibromas undergo sarcomatous transformation in approximately 5% of patients with neurofibromatosis type I. The clinical and radiologic diagnosis of sarcomatous change remains difficult. Positron emission tomography with F-18 fluorodeoxyglucose is a method to assess increased glucose metabolism in malignant tissue such as sarcomas. In this case report, positron emission tomography accurately distinguished malignant from benign neurofibromas. The technique may be useful as a noninvasive screening tool for malignant transformation of neurofibromas.

Original languageEnglish (US)
Pages (from-to)525-528
Number of pages4
JournalClinical nuclear medicine
Volume26
Issue number6
DOIs
StatePublished - May 22 2001

Keywords

  • F-18 Fluorodeoxyglucose
  • Malignant Degeneration
  • Neurofibromatosis
  • Positron Emission Tomography
  • Sarcoma

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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