Positron emission tomography imaging of neuroinflammation

Sujatha Kannan, Bindu Balakrishnan, Otto Muzik, Roberto Romero, Diane Chugani

Research output: Contribution to journalArticlepeer-review

Abstract

Injury to the central nervous system is characterized by localization of activated microglia at the site of injury. The peripheral benzodiazepine receptor expressed on the outer mitochondrial membrane of the activated microglia is a sensitive biomarker for the detection of this neuroinflammatory response to an insult. PK11195, an isoquinoline ligand that specifically binds peripheral benzodiazepine receptor, can be tagged with a positron emitter and used as a tracer for molecular imaging of this receptor in vivo by positron emission tomography (PET). [11C](R)PK11195 has been used in the imaging of various neuroinflammatory disorders, such as Alzheimer disease and multiple sclerosis. On the basis of our small-animal PET imaging studies using a neonatal rabbit model of maternal inflammation-induced cerebral palsy, we propose that PET imaging using [11C](R)PK11195 may be a valuable tool for detecting neuroinflammation in the brain of newborns born to mothers with chorioamnionitis.

Original languageEnglish (US)
Pages (from-to)1190-1199
Number of pages10
JournalJournal of child neurology
Volume24
Issue number9
DOIs
StatePublished - Sep 25 2009
Externally publishedYes

Keywords

  • Neuroinflammation
  • PET

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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