Positively charged termini of the L2 minor capsid protein are necessary for papillomavirus infection

Richard S Roden, P. M. Day, B. K. Bronzo, W. H. Yutzy IV, Y. Yang, D. R. Lowy, J. T. Schiller

Research output: Contribution to journalArticle

Abstract

Coexpression of bovine papillomavirus L1 with L2 mutants lacking either eight N-terminal or nine C-terminal amino acids that encode positively charged domains resulted in wild-type levels of viral genome encapsidation. Despite wild-type binding to the cell surface, the resulting virions were noninfectious. An L2 mutant encoding a scrambled version of the nine C-terminal residues restored infectivity, in contrast to an L2 mutant encoding a scrambled version of the N-terminal residues.

Original languageEnglish (US)
Pages (from-to)10493-10497
Number of pages5
JournalJournal of Virology
Volume75
Issue number21
DOIs
StatePublished - 2001

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Papillomavirus Infections
Papillomaviridae
Viral Genome
Capsid Proteins
coat proteins
Virion
Amino Acids
mutants
Bovine papillomavirus
infection
virion
pathogenicity
amino acids
genome
cells

ASJC Scopus subject areas

  • Immunology

Cite this

Positively charged termini of the L2 minor capsid protein are necessary for papillomavirus infection. / Roden, Richard S; Day, P. M.; Bronzo, B. K.; Yutzy IV, W. H.; Yang, Y.; Lowy, D. R.; Schiller, J. T.

In: Journal of Virology, Vol. 75, No. 21, 2001, p. 10493-10497.

Research output: Contribution to journalArticle

Roden, Richard S ; Day, P. M. ; Bronzo, B. K. ; Yutzy IV, W. H. ; Yang, Y. ; Lowy, D. R. ; Schiller, J. T. / Positively charged termini of the L2 minor capsid protein are necessary for papillomavirus infection. In: Journal of Virology. 2001 ; Vol. 75, No. 21. pp. 10493-10497.
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AU - Schiller, J. T.

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