Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA Schizophrenia consortium

Karolinska Schizophrenia Project Consortium (KaSP)

Research output: Contribution to journalArticle

Abstract

Objective: Based on the role of the superior temporal gyrus (STG) in auditory processing, language comprehension and self-monitoring, this study aimed to investigate the relationship between STG cortical thickness and positive symptom severity in schizophrenia. Method: This prospective meta-analysis includes data from 1987 individuals with schizophrenia collected at seventeen centres around the world that contribute to the ENIGMA Schizophrenia Working Group. STG thickness measures were extracted from T1-weighted brain scans using FreeSurfer. The study performed a meta-analysis of effect sizes across sites generated by a model predicting left or right STG thickness with a positive symptom severity score (harmonized SAPS or PANSS-positive scores), while controlling for age, sex and site. Secondary models investigated relationships between antipsychotic medication, duration of illness, overall illness severity, handedness and STG thickness. Results: Positive symptom severity was negatively related to STG thickness in both hemispheres (left: βstd = −0.052; P = 0.021; right: βstd = −0.073; P = 0.001) when statistically controlling for age, sex and site. This effect remained stable in models including duration of illness, antipsychotic medication or handedness. Conclusion: Our findings further underline the important role of the STG in hallmark symptoms in schizophrenia. These findings can assist in advancing insight into symptom-relevant pathophysiological mechanisms in schizophrenia.

Original languageEnglish (US)
Pages (from-to)439-447
Number of pages9
JournalActa Psychiatrica Scandinavica
Volume135
Issue number5
DOIs
StatePublished - May 1 2017
Externally publishedYes

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Temporal Lobe
Schizophrenia
Functional Laterality
Antipsychotic Agents
Meta-Analysis
Language
Brain

Keywords

  • cortical thickness
  • ENIGMA
  • FreeSurfer
  • MRI
  • positive and negative syndrome scale
  • positive symptoms
  • scale for the assessment of positive symptoms
  • schizophrenia
  • superior temporal gyrus

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA Schizophrenia consortium. / Karolinska Schizophrenia Project Consortium (KaSP).

In: Acta Psychiatrica Scandinavica, Vol. 135, No. 5, 01.05.2017, p. 439-447.

Research output: Contribution to journalArticle

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abstract = "Objective: Based on the role of the superior temporal gyrus (STG) in auditory processing, language comprehension and self-monitoring, this study aimed to investigate the relationship between STG cortical thickness and positive symptom severity in schizophrenia. Method: This prospective meta-analysis includes data from 1987 individuals with schizophrenia collected at seventeen centres around the world that contribute to the ENIGMA Schizophrenia Working Group. STG thickness measures were extracted from T1-weighted brain scans using FreeSurfer. The study performed a meta-analysis of effect sizes across sites generated by a model predicting left or right STG thickness with a positive symptom severity score (harmonized SAPS or PANSS-positive scores), while controlling for age, sex and site. Secondary models investigated relationships between antipsychotic medication, duration of illness, overall illness severity, handedness and STG thickness. Results: Positive symptom severity was negatively related to STG thickness in both hemispheres (left: βstd = −0.052; P = 0.021; right: βstd = −0.073; P = 0.001) when statistically controlling for age, sex and site. This effect remained stable in models including duration of illness, antipsychotic medication or handedness. Conclusion: Our findings further underline the important role of the STG in hallmark symptoms in schizophrenia. These findings can assist in advancing insight into symptom-relevant pathophysiological mechanisms in schizophrenia.",
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author = "{Karolinska Schizophrenia Project Consortium (KaSP)} and E. Walton and Hibar, {D. P.} and {van Erp}, {T. G.M.} and Potkin, {S. G.} and R. Roiz-Santia{\~n}ez and B. Crespo-Facorro and P. Suarez-Pinilla and {Van Haren}, {N. E.M.} and {de Zwarte}, {S. M.C.} and Kahn, {R. S.} and W. Cahn and Doan, {N. T.} and J{\o}rgensen, {K. N.} and Gurholt, {T. P.} and I. Agartz and Andreassen, {O. A.} and Westlye, {L. T.} and I. Melle and Berg, {A. O.} and L. M{\o}rch-Johnsen and A. F{\ae}rden and L. Flyckt and H. Fatouros-Bergman and J{\"o}nsson, {E. G.} and R. Hashimoto and H. Yamamori and M. Fukunaga and A. Preda and {De Rossi}, P. and F. Piras and N. Banaj and V. Ciullo and G. Spalletta and Gur, {R. E.} and Gur, {R. C.} and Wolf, {D. H.} and Satterthwaite, {T. D.} and Beard, {L. M.} and Sommer, {I. E.} and S. Koops and O. Gruber and A. Richter and B. Kr{\"a}mer and S. Kelly and G. Donohoe and C. McDonald and Cannon, {D. M.} and A. Corvin and M. Gill and Calhoun, {Vince Daniel}",
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T1 - Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA Schizophrenia consortium

AU - Karolinska Schizophrenia Project Consortium (KaSP)

AU - Walton, E.

AU - Hibar, D. P.

AU - van Erp, T. G.M.

AU - Potkin, S. G.

AU - Roiz-Santiañez, R.

AU - Crespo-Facorro, B.

AU - Suarez-Pinilla, P.

AU - Van Haren, N. E.M.

AU - de Zwarte, S. M.C.

AU - Kahn, R. S.

AU - Cahn, W.

AU - Doan, N. T.

AU - Jørgensen, K. N.

AU - Gurholt, T. P.

AU - Agartz, I.

AU - Andreassen, O. A.

AU - Westlye, L. T.

AU - Melle, I.

AU - Berg, A. O.

AU - Mørch-Johnsen, L.

AU - Færden, A.

AU - Flyckt, L.

AU - Fatouros-Bergman, H.

AU - Jönsson, E. G.

AU - Hashimoto, R.

AU - Yamamori, H.

AU - Fukunaga, M.

AU - Preda, A.

AU - De Rossi, P.

AU - Piras, F.

AU - Banaj, N.

AU - Ciullo, V.

AU - Spalletta, G.

AU - Gur, R. E.

AU - Gur, R. C.

AU - Wolf, D. H.

AU - Satterthwaite, T. D.

AU - Beard, L. M.

AU - Sommer, I. E.

AU - Koops, S.

AU - Gruber, O.

AU - Richter, A.

AU - Krämer, B.

AU - Kelly, S.

AU - Donohoe, G.

AU - McDonald, C.

AU - Cannon, D. M.

AU - Corvin, A.

AU - Gill, M.

AU - Calhoun, Vince Daniel

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Objective: Based on the role of the superior temporal gyrus (STG) in auditory processing, language comprehension and self-monitoring, this study aimed to investigate the relationship between STG cortical thickness and positive symptom severity in schizophrenia. Method: This prospective meta-analysis includes data from 1987 individuals with schizophrenia collected at seventeen centres around the world that contribute to the ENIGMA Schizophrenia Working Group. STG thickness measures were extracted from T1-weighted brain scans using FreeSurfer. The study performed a meta-analysis of effect sizes across sites generated by a model predicting left or right STG thickness with a positive symptom severity score (harmonized SAPS or PANSS-positive scores), while controlling for age, sex and site. Secondary models investigated relationships between antipsychotic medication, duration of illness, overall illness severity, handedness and STG thickness. Results: Positive symptom severity was negatively related to STG thickness in both hemispheres (left: βstd = −0.052; P = 0.021; right: βstd = −0.073; P = 0.001) when statistically controlling for age, sex and site. This effect remained stable in models including duration of illness, antipsychotic medication or handedness. Conclusion: Our findings further underline the important role of the STG in hallmark symptoms in schizophrenia. These findings can assist in advancing insight into symptom-relevant pathophysiological mechanisms in schizophrenia.

AB - Objective: Based on the role of the superior temporal gyrus (STG) in auditory processing, language comprehension and self-monitoring, this study aimed to investigate the relationship between STG cortical thickness and positive symptom severity in schizophrenia. Method: This prospective meta-analysis includes data from 1987 individuals with schizophrenia collected at seventeen centres around the world that contribute to the ENIGMA Schizophrenia Working Group. STG thickness measures were extracted from T1-weighted brain scans using FreeSurfer. The study performed a meta-analysis of effect sizes across sites generated by a model predicting left or right STG thickness with a positive symptom severity score (harmonized SAPS or PANSS-positive scores), while controlling for age, sex and site. Secondary models investigated relationships between antipsychotic medication, duration of illness, overall illness severity, handedness and STG thickness. Results: Positive symptom severity was negatively related to STG thickness in both hemispheres (left: βstd = −0.052; P = 0.021; right: βstd = −0.073; P = 0.001) when statistically controlling for age, sex and site. This effect remained stable in models including duration of illness, antipsychotic medication or handedness. Conclusion: Our findings further underline the important role of the STG in hallmark symptoms in schizophrenia. These findings can assist in advancing insight into symptom-relevant pathophysiological mechanisms in schizophrenia.

KW - cortical thickness

KW - ENIGMA

KW - FreeSurfer

KW - MRI

KW - positive and negative syndrome scale

KW - positive symptoms

KW - scale for the assessment of positive symptoms

KW - schizophrenia

KW - superior temporal gyrus

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U2 - 10.1111/acps.12718

DO - 10.1111/acps.12718

M3 - Article

VL - 135

SP - 439

EP - 447

JO - Acta Psychiatrica Scandinavica

JF - Acta Psychiatrica Scandinavica

SN - 0001-690X

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