Positive feedback loops between inflammatory, bone and cancer cells during metastatic niche construction

Ardeshir Kianercy, Kenneth Pienta

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Bone, which includes several cell populations and numerous cytokines and chemokines that provide cell-cell signaling, is a common destination for many cancer metastases. Bone metastasis skews this signaling to develop vicious cycles between immune, bone and cancer populations that lead to abnormal bone remodeling during cancer niche construction. Temporal models utilize positive feedback systems as an integrative tool providing insights into the rate-limiting processes that determine multiple stages of the bone metastasis. We develop a logical-transient-threshold framework by linking temporal responses of the cancer, bone and immune systems through macrophages during ecological niche construction of cancer in host bone.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages137-148
Number of pages12
Volume936
DOIs
StatePublished - Oct 1 2016

Publication series

NameAdvances in Experimental Medicine and Biology
Volume936
ISSN (Print)00652598
ISSN (Electronic)22148019

Keywords

  • Bone metastasis
  • Cancer ecology
  • Feedback systems
  • Tumor vicious cycle

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Kianercy, A., & Pienta, K. (2016). Positive feedback loops between inflammatory, bone and cancer cells during metastatic niche construction. In Advances in Experimental Medicine and Biology (Vol. 936, pp. 137-148). (Advances in Experimental Medicine and Biology; Vol. 936). Springer New York LLC. https://doi.org/10.1007/978-3-319-42023-3_7