Positive effects of methylphenidate on social communication and self-regulation in children with pervasive developmental disorders and hyperactivity

Laudan B. Jahromi, Connie L. Kasari, James T. McCracken, Lisa S.Y. Lee, Michael G. Aman, Christopher J. McDougle, Lawrence Scahill, Elaine Tierney, L. Eugene Arnold, Benedetto Vitiello, Louise Ritz, Andrea Witwer, Erin Kustan, Jaswinder Ghuman, David J. Posey

Research output: Contribution to journalArticle

Abstract

This report examined the effect of methylphenidate on social communication and self-regulation in children with pervasive developmental disorders and hyperactivity in a secondary analysis of RUPP Autism Network data. Participants were 33 children (29 boys) between the ages of 5 and 13 years who participated in a four-week crossover trial of placebo and increasing doses of methylphenidate given in random order each for one week. Observational measures of certain aspects of children's social communication, self-regulation, and affective behavior were obtained each week. A significant positive effect of methylphenidate was seen on children's use of joint attention initiations, response to bids for joint attention, self-regulation, and regulated affective state. The results go beyond the recent literature and suggest that methylphenidate may have positive effects on social behaviors in children with PDD and hyperactivity.

Original languageEnglish (US)
Pages (from-to)395-404
Number of pages10
JournalJournal of Autism and Developmental Disorders
Volume39
Issue number3
DOIs
StatePublished - Mar 1 2009

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Keywords

  • Autism spectrum disorder
  • Hyperactivity
  • Methylphenidate
  • Pervasive developmental disorders

ASJC Scopus subject areas

  • Developmental and Educational Psychology

Cite this

Jahromi, L. B., Kasari, C. L., McCracken, J. T., Lee, L. S. Y., Aman, M. G., McDougle, C. J., Scahill, L., Tierney, E., Eugene Arnold, L., Vitiello, B., Ritz, L., Witwer, A., Kustan, E., Ghuman, J., & Posey, D. J. (2009). Positive effects of methylphenidate on social communication and self-regulation in children with pervasive developmental disorders and hyperactivity. Journal of Autism and Developmental Disorders, 39(3), 395-404. https://doi.org/10.1007/s10803-008-0636-9