TY - JOUR
T1 - Positive and general psychopathology associated with specific gray matter reductions in inferior temporal regions in patients with schizophrenia
AU - Mennigen, Eva
AU - Jiang, Wenhao
AU - Calhoun, Vince D.
AU - van Erp, Theo G.M.
AU - Agartz, Ingrid
AU - Ford, Judith M.
AU - Mueller, Bryon A.
AU - Liu, Jingyu
AU - Turner, Jessica A.
N1 - Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2019/6
Y1 - 2019/6
N2 - Schizophrenia is a complex disorder that affects perception, cognition, and emotion causing symptoms such as delusions, hallucinations, and suspiciousness. Schizophrenia is also associated with structural cortical abnormalities including lower gray matter (GM) concentration, GM volume, and cortical thickness relative to healthy control individuals. However, the association between GM measures and symptom dimensions in schizophrenia is still not well understood. Here, we applied parallel independent component analysis (pICA), a higher-order statistical approach that identifies covarying patterns within two (or more) data modalities simultaneously, to link covarying brain networks of GM concentration with covarying linear combinations of the positive and negative syndrome scale (PANSS). In a large sample of patients with schizophrenia (n = 337) the association between these two data modalities was investigated. The pICA revealed a distinct PANSS profile characterized by increased delusional symptoms, suspiciousness, hallucinations, and anxiety, that was associated with a pattern of lower GM concentration in inferior temporal gyri and fusiform gyri and higher GM concentration in the sensorimotor cortex. GM alterations replicate previous findings; additionally, applying a multivariate technique, we were able to map a very specific symptom profile onto these GM alterations extending our understanding of cortical abnormalities associated with schizophrenia. Techniques like parallel ICA can reveal linked patterns of alterations across different data modalities that can help to identify biologically-informed phenotypes which might help to improve future treatment targets.
AB - Schizophrenia is a complex disorder that affects perception, cognition, and emotion causing symptoms such as delusions, hallucinations, and suspiciousness. Schizophrenia is also associated with structural cortical abnormalities including lower gray matter (GM) concentration, GM volume, and cortical thickness relative to healthy control individuals. However, the association between GM measures and symptom dimensions in schizophrenia is still not well understood. Here, we applied parallel independent component analysis (pICA), a higher-order statistical approach that identifies covarying patterns within two (or more) data modalities simultaneously, to link covarying brain networks of GM concentration with covarying linear combinations of the positive and negative syndrome scale (PANSS). In a large sample of patients with schizophrenia (n = 337) the association between these two data modalities was investigated. The pICA revealed a distinct PANSS profile characterized by increased delusional symptoms, suspiciousness, hallucinations, and anxiety, that was associated with a pattern of lower GM concentration in inferior temporal gyri and fusiform gyri and higher GM concentration in the sensorimotor cortex. GM alterations replicate previous findings; additionally, applying a multivariate technique, we were able to map a very specific symptom profile onto these GM alterations extending our understanding of cortical abnormalities associated with schizophrenia. Techniques like parallel ICA can reveal linked patterns of alterations across different data modalities that can help to identify biologically-informed phenotypes which might help to improve future treatment targets.
KW - Gray matter alterations
KW - Inferior temporal gyrus
KW - Parallel independent component analysis
KW - Positive and negative syndrome scale
KW - Schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=85061963184&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85061963184&partnerID=8YFLogxK
U2 - 10.1016/j.schres.2019.02.010
DO - 10.1016/j.schres.2019.02.010
M3 - Article
C2 - 30819594
AN - SCOPUS:85061963184
SN - 0920-9964
VL - 208
SP - 242
EP - 249
JO - Schizophrenia Research
JF - Schizophrenia Research
ER -