Posaconazole as salvage therapy in patients with chronic granulomatous disease and invasive filamentous fungal infection

Brahm H. Segal, Lisa A. Barnhart, Victoria L. Anderson, Thomas J. Walsh, Harry L. Malech, Steven M. Holland

Research output: Contribution to journalArticle

Abstract

Chronic granulomatous disease (CGD) is characterized by life-threatening bacterial and fungal infections. Treatment with posaconazole led to a complete response in 7 of 8 patients with CGD with invasive mold infections (7 proven cases and 1 possible case) after failure or intolerance of treatment with standard antifungal agents. In this preliminary study, salvage treatment with posaconazole was safe and effective.

Original languageEnglish (US)
Pages (from-to)1684-1688
Number of pages5
JournalClinical Infectious Diseases
Volume40
Issue number11
DOIs
StatePublished - Jun 1 2005
Externally publishedYes

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Chronic Granulomatous Disease
Salvage Therapy
Mycoses
Antifungal Agents
Bacterial Infections
Fungi
Therapeutics
Infection
posaconazole
Invasive Fungal Infections

ASJC Scopus subject areas

  • Immunology

Cite this

Segal, B. H., Barnhart, L. A., Anderson, V. L., Walsh, T. J., Malech, H. L., & Holland, S. M. (2005). Posaconazole as salvage therapy in patients with chronic granulomatous disease and invasive filamentous fungal infection. Clinical Infectious Diseases, 40(11), 1684-1688. https://doi.org/10.1086/430068

Posaconazole as salvage therapy in patients with chronic granulomatous disease and invasive filamentous fungal infection. / Segal, Brahm H.; Barnhart, Lisa A.; Anderson, Victoria L.; Walsh, Thomas J.; Malech, Harry L.; Holland, Steven M.

In: Clinical Infectious Diseases, Vol. 40, No. 11, 01.06.2005, p. 1684-1688.

Research output: Contribution to journalArticle

Segal, BH, Barnhart, LA, Anderson, VL, Walsh, TJ, Malech, HL & Holland, SM 2005, 'Posaconazole as salvage therapy in patients with chronic granulomatous disease and invasive filamentous fungal infection', Clinical Infectious Diseases, vol. 40, no. 11, pp. 1684-1688. https://doi.org/10.1086/430068
Segal, Brahm H. ; Barnhart, Lisa A. ; Anderson, Victoria L. ; Walsh, Thomas J. ; Malech, Harry L. ; Holland, Steven M. / Posaconazole as salvage therapy in patients with chronic granulomatous disease and invasive filamentous fungal infection. In: Clinical Infectious Diseases. 2005 ; Vol. 40, No. 11. pp. 1684-1688.
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