Posaconazole as salvage therapy in patients with chronic granulomatous disease and invasive filamentous fungal infection

Brahm H. Segal, Lisa A. Barnhart, Victoria L. Anderson, Thomas J. Walsh, Harry L. Malech, Steven M. Holland

Research output: Contribution to journalArticlepeer-review

Abstract

Chronic granulomatous disease (CGD) is characterized by life-threatening bacterial and fungal infections. Treatment with posaconazole led to a complete response in 7 of 8 patients with CGD with invasive mold infections (7 proven cases and 1 possible case) after failure or intolerance of treatment with standard antifungal agents. In this preliminary study, salvage treatment with posaconazole was safe and effective.

Original languageEnglish (US)
Pages (from-to)1684-1688
Number of pages5
JournalClinical Infectious Diseases
Volume40
Issue number11
DOIs
StatePublished - Jun 1 2005

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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