Portopulmonary hypertension: A tale of two circulations

Rohit Budhiraja; Paul M. Hassoun

doi:10.1378/chest.123.2.562

Portopulmonary hypertension: A tale of two circulations

Rohit Budhiraja, Paul M. Hassoun

School of Medicine

Research output: Contribution to journal › Review article › peer-review

135 Scopus citations

Abstract

Pulmonary involvement is common in patients with portal hypertension and can manifest in diverse manners. Changes in pulmonary arterial resistance, manifesting either as the hepatopulmonary syndrome or portopulmonary hypertension (PPHTN), have been increasingly recognized in these patients in recent years. This review summarizes the clinicopathologic features, diagnostic criteria, as well as the latest concepts in the pathogenesis and management of PPHTN, which is defined as an elevated pulmonary artery pressure in the setting of an increased pulmonary vascular resistance and a normal wedge pressure in a patient with portal hypertension.

Original language	English (US)
Pages (from-to)	562-576
Number of pages	15
Journal	CHEST
Volume	123
Issue number	2
DOIs	https://doi.org/10.1378/chest.123.2.562
State	Published - Feb 1 2003

Keywords

Endothelin
Liver
Nitric oxide
Portal hypertension
Portopulmonary hypertension
Prostacyclin
Pulmonary hypertension
Serotonin
Transplant

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Critical Care and Intensive Care Medicine
Cardiology and Cardiovascular Medicine

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10.1378/chest.123.2.562

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abstract = "Pulmonary involvement is common in patients with portal hypertension and can manifest in diverse manners. Changes in pulmonary arterial resistance, manifesting either as the hepatopulmonary syndrome or portopulmonary hypertension (PPHTN), have been increasingly recognized in these patients in recent years. This review summarizes the clinicopathologic features, diagnostic criteria, as well as the latest concepts in the pathogenesis and management of PPHTN, which is defined as an elevated pulmonary artery pressure in the setting of an increased pulmonary vascular resistance and a normal wedge pressure in a patient with portal hypertension.",

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AB - Pulmonary involvement is common in patients with portal hypertension and can manifest in diverse manners. Changes in pulmonary arterial resistance, manifesting either as the hepatopulmonary syndrome or portopulmonary hypertension (PPHTN), have been increasingly recognized in these patients in recent years. This review summarizes the clinicopathologic features, diagnostic criteria, as well as the latest concepts in the pathogenesis and management of PPHTN, which is defined as an elevated pulmonary artery pressure in the setting of an increased pulmonary vascular resistance and a normal wedge pressure in a patient with portal hypertension.

KW - Endothelin

KW - Liver

KW - Nitric oxide

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KW - Portopulmonary hypertension

KW - Prostacyclin

KW - Pulmonary hypertension

KW - Serotonin

KW - Transplant

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Portopulmonary hypertension: A tale of two circulations

Abstract

Keywords

ASJC Scopus subject areas

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