Portal hypertension, hepatic infarction, and liver failure complicating pancreatic islet autotransplantation

T. J. Walsh, J. C. Eggleston, John L Cameron

Research output: Contribution to journalArticle

Abstract

A patient with chronic pancreatitis who underwent subtotal pancreatectomy and pancreatic islet tissue autotransplantation by portal vein embolization developed marked portal hypertension requiring surgical portal systemic decompression. The patient subsequently developed extensive hepatic infarction and died of liver failure. Postmortem studies showed organizing thromboemboli containing pancreatic acinar and islet tissue in the intrahepatic portal venous radicles and widespread ischemic infarcts with periportal sparing. Factors contributing to hepatic infarction were thrombosis of portal venous radicles, portasystemic shunting, and systemic arterial hypotension. Marked portal hypertension, hepatic infarction, and liver failure are potential complications of pancreatic islet tissue autotransplantation.

Original languageEnglish (US)
Pages (from-to)485-487
Number of pages3
JournalSurgery
Volume91
Issue number4
StatePublished - 1982

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Autologous Transplantation
Liver Failure
Portal Hypertension
Islets of Langerhans
Infarction
Pancreatectomy
Liver
Chronic Pancreatitis
Portal Vein
Decompression
Venous Thrombosis
Hypotension

ASJC Scopus subject areas

  • Surgery

Cite this

Portal hypertension, hepatic infarction, and liver failure complicating pancreatic islet autotransplantation. / Walsh, T. J.; Eggleston, J. C.; Cameron, John L.

In: Surgery, Vol. 91, No. 4, 1982, p. 485-487.

Research output: Contribution to journalArticle

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