Porphyria cutanea tarda exacerbation as a paraneoplastic syndrome in vaginal cancer resolved with chemoradiation

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Abstract

Porphyria Cutanea Tarda (PCT) is a rare paraneoplastic syndrome. The effects of therapeutic ionizing radiation in patients with PCT are not well understood. We report the case of a 55 year-old woman with a past medical history significant for kidney transplant with rejection and removal on hemodialysis, Stevens-Johnson syndrome, porphyria cutanea tarda, undifferentiated connective tissue disease probably systemic lupus, and hepatitis C, who underwent curative chemoradiation treatment for a recurrent vaginal squamous cell carcinoma. There was no increased acute toxicity and active porphyria cutanea tarda improved over the course of radiation treatment and fully resolved within 1 year. However, there was significant myofibrotic late toxicity within the treated region.

Original languageEnglish (US)
Article number100682
JournalGynecologic Oncology Reports
Volume35
DOIs
StatePublished - Feb 2021

Keywords

  • Ionizing radiation
  • Porphyria cutanea tarda
  • Radiation
  • Vaginal cancer

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

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