Abstract
Porphyria Cutanea Tarda (PCT) is a rare paraneoplastic syndrome. The effects of therapeutic ionizing radiation in patients with PCT are not well understood. We report the case of a 55 year-old woman with a past medical history significant for kidney transplant with rejection and removal on hemodialysis, Stevens-Johnson syndrome, porphyria cutanea tarda, undifferentiated connective tissue disease probably systemic lupus, and hepatitis C, who underwent curative chemoradiation treatment for a recurrent vaginal squamous cell carcinoma. There was no increased acute toxicity and active porphyria cutanea tarda improved over the course of radiation treatment and fully resolved within 1 year. However, there was significant myofibrotic late toxicity within the treated region.
Original language | English (US) |
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Article number | 100682 |
Journal | Gynecologic Oncology Reports |
Volume | 35 |
DOIs | |
State | Published - Feb 2021 |
Keywords
- Ionizing radiation
- Porphyria cutanea tarda
- Radiation
- Vaginal cancer
ASJC Scopus subject areas
- Oncology
- Obstetrics and Gynecology