Poroelastography: Imaging the poroelastic properties of tissues

Elisa E. Konofagou, Timothy Harrigan, Jonathan Ophir, Thomas A. Krouskop

Research output: Contribution to journalArticle

Abstract

In the field of elastography, biological tissues are conveniently assumed to be purely elastic solids. However, several tissues, including brain, cartilage and edematous soft tissues, have long been known to be poroelastic. The objective of this study is to show the feasibility of imaging the poroelastic properties of tissue-like materials. A poroelastic material is a material saturated with fluid that flows relative to a deforming solid matrix. In this paper, we describe a method for estimating the poroelastic attributes of tissues. It has been analytically shown that during stress relaxation of a poroelastic material (i.e., sustained application of a constant applied strain over time), the lateral-to-axial strain ratio decreases exponentially with time toward the Poisson's ratio of the solid matrix. The time constant of this variation depends on the elastic modulus of the solid matrix, its permeability and its dimension along the direction of fluid flow. Recently, we described an elastographic method that can be used to map axial and lateral tissue strains. In this study, we use the same method in a stress relaxation case to measure the time-dependent lateral-to-axial strain ratio in poroelastic materials. The resulting time-sequenced images (poroelastograms) depict the spatial distribution of the fluid within the solid at each time instant, and help to differentiate poroelastic materials of distinct Poisson's ratios and permeabilities of the solid matrix. Results are shown from finite-element simulations.

Original languageEnglish (US)
Pages (from-to)1387-1397
Number of pages11
JournalUltrasound in Medicine and Biology
Volume27
Issue number10
DOIs
StatePublished - Jan 1 2001
Externally publishedYes

Fingerprint

axial strain
stress relaxation
Poisson ratio
matrices
fluid flow
Permeability
permeability
Elasticity Imaging Techniques
cartilage
Elastic Modulus
time constant
Cartilage
brain
modulus of elasticity
spatial distribution
estimating
fluids
Brain
simulation
Direction compound

Keywords

  • Elasticity
  • Elastography
  • Imaging
  • Permeability
  • Poisson's ratio
  • Poroelastic
  • Poroelastogram
  • Strain ratio
  • Stress relaxation
  • Ultrasound

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Biophysics
  • Acoustics and Ultrasonics

Cite this

Poroelastography : Imaging the poroelastic properties of tissues. / Konofagou, Elisa E.; Harrigan, Timothy; Ophir, Jonathan; Krouskop, Thomas A.

In: Ultrasound in Medicine and Biology, Vol. 27, No. 10, 01.01.2001, p. 1387-1397.

Research output: Contribution to journalArticle

Konofagou, Elisa E. ; Harrigan, Timothy ; Ophir, Jonathan ; Krouskop, Thomas A. / Poroelastography : Imaging the poroelastic properties of tissues. In: Ultrasound in Medicine and Biology. 2001 ; Vol. 27, No. 10. pp. 1387-1397.
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