TY - JOUR
T1 - Porcine acellular dermal matrix for hernia repair in transplant patients
AU - Gowda, Arvind U.
AU - McNichols, Colton H.L.
AU - Asokan, Ishan
AU - Matthews, Jamil A.
AU - Buckingham, E. Bryan
AU - Sabino, Jennifer
AU - Maddox, John S.
AU - Slezak, Sheri
AU - Rasko, Yvonne
AU - Singh, Devinder P.
N1 - Publisher Copyright:
Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2016/11/28
Y1 - 2016/11/28
N2 - Purpose: The purpose of this study was to compare clinical outcomes of incisional hernia repair in solid organ transplant patients using non-cross-linked porcine acellular dermal matrix (PADM), human derived acellular dermal matrix (HADM) and synthetic mesh. Methods: A retrospective review of patients who underwent hernia repair with PADMafter pancreas and/or renal transplant at the University ofMarylandMedical Center from 2008 to 2012 was conducted. Repair type, postoperative infection, hernia recurrence, mesh removal, and length of follow-up were recorded. Results were compared with our previously published data evaluating HADM and synthetic mesh used in transplant patients between 2000 and 2005. Results: Twenty-seven patients underwent ventral hernia repair with PADM, 34 patients were repaired with HADM and 26 were repaired with synthetic mesh. The rate of wound infection in those repaired with PADM, HADM, and synthetic mesh were 14.8%, 14.7%, and 65.4%, respectively. Rates of recurrence were 13.3%, 23.5%, and 76.9%, respectively. Rate of mesh removal was found to be 7.4%, 11.8%, and 69.2%, respectively. These complication rates were significantly lower in patients who received HADM or PADM compared with patients repaired with synthetic mesh (P < 0.001). There was no statistically significant difference in the outcomes between the groups repaired with HADM or PADM. Conclusions: The use of PADM for incisional hernia repair after kidney and/or pancreas transplant significantly reduces the incidence of hernia recurrence, wound infection, and need for mesh removal compared to synthetic mesh. No difference in morbidity between HADM and PADM was observed in the study population; however, longer follow-up in the PADM group is warranted.
AB - Purpose: The purpose of this study was to compare clinical outcomes of incisional hernia repair in solid organ transplant patients using non-cross-linked porcine acellular dermal matrix (PADM), human derived acellular dermal matrix (HADM) and synthetic mesh. Methods: A retrospective review of patients who underwent hernia repair with PADMafter pancreas and/or renal transplant at the University ofMarylandMedical Center from 2008 to 2012 was conducted. Repair type, postoperative infection, hernia recurrence, mesh removal, and length of follow-up were recorded. Results were compared with our previously published data evaluating HADM and synthetic mesh used in transplant patients between 2000 and 2005. Results: Twenty-seven patients underwent ventral hernia repair with PADM, 34 patients were repaired with HADM and 26 were repaired with synthetic mesh. The rate of wound infection in those repaired with PADM, HADM, and synthetic mesh were 14.8%, 14.7%, and 65.4%, respectively. Rates of recurrence were 13.3%, 23.5%, and 76.9%, respectively. Rate of mesh removal was found to be 7.4%, 11.8%, and 69.2%, respectively. These complication rates were significantly lower in patients who received HADM or PADM compared with patients repaired with synthetic mesh (P < 0.001). There was no statistically significant difference in the outcomes between the groups repaired with HADM or PADM. Conclusions: The use of PADM for incisional hernia repair after kidney and/or pancreas transplant significantly reduces the incidence of hernia recurrence, wound infection, and need for mesh removal compared to synthetic mesh. No difference in morbidity between HADM and PADM was observed in the study population; however, longer follow-up in the PADM group is warranted.
KW - Biologic mesh
KW - Incisional hernia
KW - Porcine acellular dermalmatrix
KW - Transplant hernia
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U2 - 10.1097/SAP.0000000000000929
DO - 10.1097/SAP.0000000000000929
M3 - Article
C2 - 27759588
AN - SCOPUS:84992108810
SN - 0148-7043
VL - 77
SP - 674
EP - 677
JO - Annals of plastic surgery
JF - Annals of plastic surgery
IS - 6
ER -