Population correlates of plasma fibrinogen and factor VII, putative cardiovascular risk factors

Aaron R. Folsom, Kenneth K. Wu, C. E. Davis, Maureen G. Conlan, Paul D. Sorlie, Moyses Szklo

Research output: Contribution to journalArticlepeer-review

Abstract

Recent prospective investigations have reported that higher plasma fibrinogen concentrations and higher factor VII coagulant activity are associated with greater risk of cardiovascular disease. To discover what characteristics may influence fibrinogen and factor VII, we analyzed data from the Atherosclerosis Risk in Communities Study obtained from over 12000 men and women, aged 45-64 years, from four communities in December 1986 to June 1989. Fibrinogen was higher in blacks than whites and in women than men; in general, it increased with age, smoking, body size, diabetes, fasting serum insulin, LDL cholesterol, lipoprotein(a), leukocyte count, and menopause, and it decreased with ethanol intake, physical activity, HDL cholesterol, and female hormone use. Factor VII was higher in women than men and, in women, increased with age; in both sexes, it increased with body size, triglycerides, LDL cholesterol, and HDL cholesterol, and it decreased with ethanol intake. These findings indicate that elevations in fibrinogen and factor VII may be modifiable through appropriate lifestyle changes.

Original languageEnglish (US)
Pages (from-to)191-205
Number of pages15
JournalAtherosclerosis
Volume91
Issue number3
DOIs
StatePublished - Dec 1991

Keywords

  • ARIC study
  • Blood coagulation factors
  • Coronary disease
  • Factor VII
  • Fibrinogen

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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