TY - JOUR
T1 - Population correlates of plasma fibrinogen and factor VII, putative cardiovascular risk factors
AU - Folsom, Aaron R.
AU - Wu, Kenneth K.
AU - Davis, C. E.
AU - Conlan, Maureen G.
AU - Sorlie, Paul D.
AU - Szklo, Moyses
N1 - Funding Information:
The authors thank Dr. John Eckfeldt, Dr. Robert Rock, Dr. Wolfgang Patsch, Dr. Spencer Brown, Dr. Woody Chambless, Dr. Frederic Romm, Audrey Papp, and Andrea Finch, of the ARIC Laboratory Committee, and Joonho Kim, Laura Kemmis, and Gretchen Marcucci for assistance in manuscript preparation. The authors also thank the following field center technicians for sample preparation: Elsie Bacon, Karen Barr, Carol Christman, Lisa Field, Amy Haire, Sharada Iyer, Bryna Lester, Stella Loehr, Barbara Mari-otti, Catherine McCormick, Gail Murton, Joan Nelling, Virginia Overman, Delilah Posey, Cathy Rachui, Sue Ware, Shirley Willis, Virginia Wyum. Support was provided by National Heart, Lung and Blood Institute Contracts Nol-Hc-55015, Nol-Hc-55016, Nol-Hc-55018, Nol-Hc-55019, Nol-Hc-55020, Nol-Hc-55021, and Nol-Hc-55022.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1991/12
Y1 - 1991/12
N2 - Recent prospective investigations have reported that higher plasma fibrinogen concentrations and higher factor VII coagulant activity are associated with greater risk of cardiovascular disease. To discover what characteristics may influence fibrinogen and factor VII, we analyzed data from the Atherosclerosis Risk in Communities Study obtained from over 12000 men and women, aged 45-64 years, from four communities in December 1986 to June 1989. Fibrinogen was higher in blacks than whites and in women than men; in general, it increased with age, smoking, body size, diabetes, fasting serum insulin, LDL cholesterol, lipoprotein(a), leukocyte count, and menopause, and it decreased with ethanol intake, physical activity, HDL cholesterol, and female hormone use. Factor VII was higher in women than men and, in women, increased with age; in both sexes, it increased with body size, triglycerides, LDL cholesterol, and HDL cholesterol, and it decreased with ethanol intake. These findings indicate that elevations in fibrinogen and factor VII may be modifiable through appropriate lifestyle changes.
AB - Recent prospective investigations have reported that higher plasma fibrinogen concentrations and higher factor VII coagulant activity are associated with greater risk of cardiovascular disease. To discover what characteristics may influence fibrinogen and factor VII, we analyzed data from the Atherosclerosis Risk in Communities Study obtained from over 12000 men and women, aged 45-64 years, from four communities in December 1986 to June 1989. Fibrinogen was higher in blacks than whites and in women than men; in general, it increased with age, smoking, body size, diabetes, fasting serum insulin, LDL cholesterol, lipoprotein(a), leukocyte count, and menopause, and it decreased with ethanol intake, physical activity, HDL cholesterol, and female hormone use. Factor VII was higher in women than men and, in women, increased with age; in both sexes, it increased with body size, triglycerides, LDL cholesterol, and HDL cholesterol, and it decreased with ethanol intake. These findings indicate that elevations in fibrinogen and factor VII may be modifiable through appropriate lifestyle changes.
KW - ARIC study
KW - Blood coagulation factors
KW - Coronary disease
KW - Factor VII
KW - Fibrinogen
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U2 - 10.1016/0021-9150(91)90167-2
DO - 10.1016/0021-9150(91)90167-2
M3 - Article
C2 - 1789804
AN - SCOPUS:0025718469
SN - 0021-9150
VL - 91
SP - 191
EP - 205
JO - Atherosclerosis
JF - Atherosclerosis
IS - 3
ER -