Poor prognosis despite aggressive treatment in adults with intramedullary spinal cord glioblastoma

Ann Liu, Eric W. Sankey, Chetan Bettegowda, Peter C. Burger, George Jallo, Mari Groves

Research output: Contribution to journalArticle

Abstract

We report our institution's experience with adult patients who underwent surgery for intramedullary spinal cord glioblastoma. Spine involvement of glioblastoma is rare, representing 7.5% of all intramedullary gliomas and 1-3% of all spinal cord tumors. We performed a retrospective review of five male patients with intramedullary spinal cord glioblastoma who underwent surgical resection from 1990 to 2014. Demographic, operative, and postoperative factors were recorded. The median age at treatment was 31 years (range: 18-61) and all men presented with motor or sensory dysfunction. Two had prior surgical resection of an intramedullary World Health Organization Grade III anaplastic astrocytoma lesion with adjuvant chemoradiation. All tumors were present in the cervical (n = 2; 40%) or thoracic (n = 3; 60%) spine, spanning a median of three levels (range: 2-4). Gross total resection was achieved in three men (60%), and there were no intraoperative mortalities or complications. Although one had improvement in his neurological status postoperatively, all five men died with a median time to death of 20 months (range: 2-31). Adult intramedullary spinal cord glioblastoma is rare, and despite aggressive treatment, prognosis is poor, with a median survival in our series of only 20 months. New treatment strategies are necessary to improve survival in this patient population.

Original languageEnglish (US)
Article number6067
Pages (from-to)1628-1631
Number of pages4
JournalJournal of Clinical Neuroscience
Volume22
Issue number10
DOIs
StatePublished - Oct 1 2015

Fingerprint

Glioblastoma
Spinal Cord
Astrocytoma
Spine
Spinal Cord Neoplasms
Survival
Therapeutics
Glioma
Thorax
Demography
Mortality
Population
Neoplasms

Keywords

  • Adult
  • Glioblastoma
  • Intramedullary
  • Oncology
  • Spine

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Physiology (medical)

Cite this

Poor prognosis despite aggressive treatment in adults with intramedullary spinal cord glioblastoma. / Liu, Ann; Sankey, Eric W.; Bettegowda, Chetan; Burger, Peter C.; Jallo, George; Groves, Mari.

In: Journal of Clinical Neuroscience, Vol. 22, No. 10, 6067, 01.10.2015, p. 1628-1631.

Research output: Contribution to journalArticle

@article{96fa1138f5864ed0929f104ed53dc161,
title = "Poor prognosis despite aggressive treatment in adults with intramedullary spinal cord glioblastoma",
abstract = "We report our institution's experience with adult patients who underwent surgery for intramedullary spinal cord glioblastoma. Spine involvement of glioblastoma is rare, representing 7.5{\%} of all intramedullary gliomas and 1-3{\%} of all spinal cord tumors. We performed a retrospective review of five male patients with intramedullary spinal cord glioblastoma who underwent surgical resection from 1990 to 2014. Demographic, operative, and postoperative factors were recorded. The median age at treatment was 31 years (range: 18-61) and all men presented with motor or sensory dysfunction. Two had prior surgical resection of an intramedullary World Health Organization Grade III anaplastic astrocytoma lesion with adjuvant chemoradiation. All tumors were present in the cervical (n = 2; 40{\%}) or thoracic (n = 3; 60{\%}) spine, spanning a median of three levels (range: 2-4). Gross total resection was achieved in three men (60{\%}), and there were no intraoperative mortalities or complications. Although one had improvement in his neurological status postoperatively, all five men died with a median time to death of 20 months (range: 2-31). Adult intramedullary spinal cord glioblastoma is rare, and despite aggressive treatment, prognosis is poor, with a median survival in our series of only 20 months. New treatment strategies are necessary to improve survival in this patient population.",
keywords = "Adult, Glioblastoma, Intramedullary, Oncology, Spine",
author = "Ann Liu and Sankey, {Eric W.} and Chetan Bettegowda and Burger, {Peter C.} and George Jallo and Mari Groves",
year = "2015",
month = "10",
day = "1",
doi = "10.1016/j.jocn.2015.05.008",
language = "English (US)",
volume = "22",
pages = "1628--1631",
journal = "Journal of Clinical Neuroscience",
issn = "0967-5868",
publisher = "Churchill Livingstone",
number = "10",

}

TY - JOUR

T1 - Poor prognosis despite aggressive treatment in adults with intramedullary spinal cord glioblastoma

AU - Liu, Ann

AU - Sankey, Eric W.

AU - Bettegowda, Chetan

AU - Burger, Peter C.

AU - Jallo, George

AU - Groves, Mari

PY - 2015/10/1

Y1 - 2015/10/1

N2 - We report our institution's experience with adult patients who underwent surgery for intramedullary spinal cord glioblastoma. Spine involvement of glioblastoma is rare, representing 7.5% of all intramedullary gliomas and 1-3% of all spinal cord tumors. We performed a retrospective review of five male patients with intramedullary spinal cord glioblastoma who underwent surgical resection from 1990 to 2014. Demographic, operative, and postoperative factors were recorded. The median age at treatment was 31 years (range: 18-61) and all men presented with motor or sensory dysfunction. Two had prior surgical resection of an intramedullary World Health Organization Grade III anaplastic astrocytoma lesion with adjuvant chemoradiation. All tumors were present in the cervical (n = 2; 40%) or thoracic (n = 3; 60%) spine, spanning a median of three levels (range: 2-4). Gross total resection was achieved in three men (60%), and there were no intraoperative mortalities or complications. Although one had improvement in his neurological status postoperatively, all five men died with a median time to death of 20 months (range: 2-31). Adult intramedullary spinal cord glioblastoma is rare, and despite aggressive treatment, prognosis is poor, with a median survival in our series of only 20 months. New treatment strategies are necessary to improve survival in this patient population.

AB - We report our institution's experience with adult patients who underwent surgery for intramedullary spinal cord glioblastoma. Spine involvement of glioblastoma is rare, representing 7.5% of all intramedullary gliomas and 1-3% of all spinal cord tumors. We performed a retrospective review of five male patients with intramedullary spinal cord glioblastoma who underwent surgical resection from 1990 to 2014. Demographic, operative, and postoperative factors were recorded. The median age at treatment was 31 years (range: 18-61) and all men presented with motor or sensory dysfunction. Two had prior surgical resection of an intramedullary World Health Organization Grade III anaplastic astrocytoma lesion with adjuvant chemoradiation. All tumors were present in the cervical (n = 2; 40%) or thoracic (n = 3; 60%) spine, spanning a median of three levels (range: 2-4). Gross total resection was achieved in three men (60%), and there were no intraoperative mortalities or complications. Although one had improvement in his neurological status postoperatively, all five men died with a median time to death of 20 months (range: 2-31). Adult intramedullary spinal cord glioblastoma is rare, and despite aggressive treatment, prognosis is poor, with a median survival in our series of only 20 months. New treatment strategies are necessary to improve survival in this patient population.

KW - Adult

KW - Glioblastoma

KW - Intramedullary

KW - Oncology

KW - Spine

UR - http://www.scopus.com/inward/record.url?scp=84941182222&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84941182222&partnerID=8YFLogxK

U2 - 10.1016/j.jocn.2015.05.008

DO - 10.1016/j.jocn.2015.05.008

M3 - Article

VL - 22

SP - 1628

EP - 1631

JO - Journal of Clinical Neuroscience

JF - Journal of Clinical Neuroscience

SN - 0967-5868

IS - 10

M1 - 6067

ER -