Pooling data when analyzing biomarkers subject to a limit of detection

Leslie Rosenthal, Enrique Schisterman

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The use of biomarkers to assess exposure and investigate biomedical questions is common in epidemiology. The usefulness of biomarker research, however, is contingent upon the ability to achieve a complete understanding of the role they play within a population. In estimating distributional parameters for a particular biomarker, such as oxidative stress or antioxidant markers, scientists face two main challenges: overcoming the cost of performing a large number of assays and dealing with data subject to a limit of detection. While approaches have been suggested to deal with each of these issues individually, pooling is a strategy that can address both problems.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
Pages421-426
Number of pages6
Volume477
DOIs
StatePublished - 2008
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume477
ISSN (Print)10643745

Fingerprint

Limit of Detection
Meta-Analysis
Biomarkers
Epidemiology
Oxidative Stress
Antioxidants
Costs and Cost Analysis
Research
Population

Keywords

  • Biomarkers
  • Detection limit
  • Pooling

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

Rosenthal, L., & Schisterman, E. (2008). Pooling data when analyzing biomarkers subject to a limit of detection. In Methods in Molecular Biology (Vol. 477, pp. 421-426). (Methods in Molecular Biology; Vol. 477). https://doi.org/10.1007/978-1-60327-517-0_31

Pooling data when analyzing biomarkers subject to a limit of detection. / Rosenthal, Leslie; Schisterman, Enrique.

Methods in Molecular Biology. Vol. 477 2008. p. 421-426 (Methods in Molecular Biology; Vol. 477).

Research output: Chapter in Book/Report/Conference proceedingChapter

Rosenthal, L & Schisterman, E 2008, Pooling data when analyzing biomarkers subject to a limit of detection. in Methods in Molecular Biology. vol. 477, Methods in Molecular Biology, vol. 477, pp. 421-426. https://doi.org/10.1007/978-1-60327-517-0_31
Rosenthal L, Schisterman E. Pooling data when analyzing biomarkers subject to a limit of detection. In Methods in Molecular Biology. Vol. 477. 2008. p. 421-426. (Methods in Molecular Biology). https://doi.org/10.1007/978-1-60327-517-0_31
Rosenthal, Leslie ; Schisterman, Enrique. / Pooling data when analyzing biomarkers subject to a limit of detection. Methods in Molecular Biology. Vol. 477 2008. pp. 421-426 (Methods in Molecular Biology).
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