@inbook{0b62de17c4644203ac2599254c283df1,
title = "Pooling data when analyzing biomarkers subject to a limit of detection",
abstract = "The use of biomarkers to assess exposure and investigate biomedical questions is common in epidemiology. The usefulness of biomarker research, however, is contingent upon the ability to achieve a complete understanding of the role they play within a population. In estimating distributional parameters for a particular biomarker, such as oxidative stress or antioxidant markers, scientists face two main challenges: overcoming the cost of performing a large number of assays and dealing with data subject to a limit of detection. While approaches have been suggested to deal with each of these issues individually, pooling is a strategy that can address both problems.",
keywords = "Biomarkers, Detection limit, Pooling",
author = "Leslie Rosenthal and Enrique Schisterman",
year = "2008",
doi = "10.1007/978-1-60327-517-0_31",
language = "English (US)",
isbn = "9781603272186",
series = "Methods in Molecular Biology",
pages = "421--426",
editor = "Donald Armstrong and Donald Armstrong and Donald Armstrong",
booktitle = "Advanced Protocols in Oxidative Stress I",
}