Polysomnography in preterm infants and children with chronic lung disease

Sharon A. McGrath-Morrow, Timothy Ryan, Brian M. McGinley, Sande O. Okelo, Laura M. Sterni, J. Michael Collaco

Research output: Contribution to journalReview articlepeer-review

Abstract

Objective To determine the utility of overnight polysomnography (PSG) in assessing pulmonary reserve in stable preterm children with chronic lung disease (CLD). Study design A retrospective review and descriptive study of overnight PSGs and clinic visits of preterm infants/children less than 3 years of age who were diagnosed with bronchopulmonary dysplasia at discharge from the hospital and enrolled in the Johns Hopkins CLD patient registry between 2008 and 2010. Results Sixty-two clinically stable patients underwent at least one overnight polysomnogram for clinical indications. The majority of patients were referred for oxygen titration (71%). PSGs from first studies revealed a mean respiratory disturbance index (RDI) of 8.2±10.1 events/hr and a mean O 2 saturation (SaO 2) nadir of 86.2±5.7%. In patients who underwent more than one PSG (n=23), a significant decrease in RDI (P<0.001) was found between the first study (mean age: 8.0±3.3 months) and second study (mean age: 13.4±5.2 months). Outpatient clinical measures of mean room air SaO 2 and respiratory rate were not predictive of PSG measures of RDI and SaO 2 nadir. Conclusion Mean RDI was higher in stable preterm infants/children with CLD compared to previously published controls. RDI decreased with age in stable preterm infants/children with CLD suggesting improved pulmonary reserve with age. Outpatient clinical measures (respiratory rate and room air SaO 2) did not correlate with RDI and SaO 2 nadir indicating that overnight PSG is more sensitive in assessing pulmonary reserve than outpatient clinical measures.

Original languageEnglish (US)
Pages (from-to)172-179
Number of pages8
JournalPediatric pulmonology
Volume47
Issue number2
DOIs
StatePublished - Feb 2012

Keywords

  • bronchopulmonary dysplasia
  • polysomnography
  • prematurity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

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