Polyoma viruses with mutations at endonuclease HindII site 1: Alterations at the COOH terminus of VP1

M. M. Bendig, W. R. Folk, W. Gibson

Research output: Contribution to journalArticlepeer-review

Abstract

Four mutants of polyoma virus lacking endonuclease HindII site I were isolated and characterized with respect to the VP1 coding sequence. Three of these mutants had deletions that removed 0.2 to 0.3% of the genome. All three deletion mutants encoded VP1 proteins that were smaller than wild type and that lacked one or more tryptic peptides normally found in the wild-type VP1 protein. Our results suggest that Hind II site I is at, or very near, the carboxy terminal end of the coding sequence for VP1. A model for the peptide organization in that region is presented.

Original languageEnglish (US)
Pages (from-to)515-522
Number of pages8
JournalJournal of virology
Volume30
Issue number2
DOIs
StatePublished - 1979
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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