Abstract
Objective: To assess the association between polymorphisms within the interferon-γ receptor gene (IFN-γR) and systemic lupus erythematosus (SLE) in Chinese people. Methods: The IFN-γR genotypes of 94 SLE patients and 80 healthy subjects were examined by the reverse transcription-polymerase chain reaction (RT-PCR)-single-strand conformation polymorphism (SSCP) method, RT-PCR-restriction fragment length polymorphism (RFLP) method and DNA sequencing. Results: There was no statistically significant difference in the IFN-γR genotype frequencies between the two groups. The IFN-γR2 Arg64/Arg64 genotype decreased the risk of SLE (OR = 2.481, 95% CI 0.992-6. 203, P = 0.047). The decreased risk of the development of SLE was detected in the individuals who had the combination of IFN-γR2 Arg64/Arg64 genotype and IFN-γR1 Val14/Val14 genotype (OR = 2.481, 95% CI 0.992-6.203, P = 0.047). Conclusion: The IFN-γR2 Arg64/Arg64 genotype does not determine susceptibility to SLE in Chinese people, and the combination of IFN-γR2 Arg64/Arg64 genotype and IFN-γR1 Val14/Val14 genotype does not, either.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 320-323 |
| Number of pages | 4 |
| Journal | Chinese Journal of Medical Genetics |
| Volume | 22 |
| Issue number | 3 |
| State | Published - Jun 2005 |
| Externally published | Yes |
Keywords
- Interferon-γ receptor
- Polymorphism
- Systemic lupus erythematosus
ASJC Scopus subject areas
- Genetics(clinical)
- Bioengineering