Polymorphisms within the interferon-γ receptor associated with systemic lupus erythematosus

Xu Yao, Yu Mei Li, Zi Jia Hu, Wen Zhong Li, Zhi Qiang Chen

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To assess the association between polymorphisms within the interferon-γ receptor gene (IFN-γR) and systemic lupus erythematosus (SLE) in Chinese people. Methods: The IFN-γR genotypes of 94 SLE patients and 80 healthy subjects were examined by the reverse transcription-polymerase chain reaction (RT-PCR)-single-strand conformation polymorphism (SSCP) method, RT-PCR-restriction fragment length polymorphism (RFLP) method and DNA sequencing. Results: There was no statistically significant difference in the IFN-γR genotype frequencies between the two groups. The IFN-γR2 Arg64/Arg64 genotype decreased the risk of SLE (OR = 2.481, 95% CI 0.992-6. 203, P = 0.047). The decreased risk of the development of SLE was detected in the individuals who had the combination of IFN-γR2 Arg64/Arg64 genotype and IFN-γR1 Val14/Val14 genotype (OR = 2.481, 95% CI 0.992-6.203, P = 0.047). Conclusion: The IFN-γR2 Arg64/Arg64 genotype does not determine susceptibility to SLE in Chinese people, and the combination of IFN-γR2 Arg64/Arg64 genotype and IFN-γR1 Val14/Val14 genotype does not, either.

Original languageEnglish (US)
Pages (from-to)320-323
Number of pages4
JournalChinese Journal of Medical Genetics
Volume22
Issue number3
StatePublished - Jun 2005
Externally publishedYes

Keywords

  • Interferon-γ receptor
  • Polymorphism
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Genetics(clinical)
  • Bioengineering

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