@article{5acd5f3e94a44733923a8f4d2297737e,
title = "Polymorphisms of the HNF1A Gene Encoding Hepatocyte Nuclear Factor-1α are Associated with C-Reactive Protein",
abstract = "Data from the Pharmacogenomics and Risk of Cardiovascular Disease (PARC) study and the Cardiovascular Health Study (CHS) provide independent and confirmatory evidence for association between common polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1α and plasma C-reactive protein (CRP) concentration. Analyses with the use of imputation-based methods to combine genotype data from both studies and to test untyped SNPs from the HapMap database identified several SNPs within a 5 kb region of HNF1A intron 1 with the strongest evidence of association with CRP phenotype.",
author = "Reiner, {Alexander P.} and Barber, {Mathew J.} and Yongtao Guan and Ridker, {Paul M.} and Lange, {Leslie A.} and Chasman, {Daniel I I.} and Walston, {Jeremy D.} and Cooper, {Gregory M.} and Jenny, {Nancy S.} and Rieder, {Mark J.} and Durda, {J. Peter} and Smith, {Joshua D.} and John Novembre and Tracy, {Russell P.} and Rotter, {Jerome I.} and Matthew Stephens and Nickerson, {Deborah A.} and Krauss, {Ronald M.}",
note = "Funding Information: The authors thank Jiong Zhang for providing assistance with the PARC-data analysis. The research reported in this article was supported by PARC grants U01 HL-069757 (R.M.K) and U01 HL084689 (M.S.); CHS contracts N01-HC-85079–N01-HC-85086, N01-HC-35129, N01 HC-15103, and N01 HC-55222; and CHS grants U01 HL080295 and R01 HL-071862 (A.P.R.) from the National Heart, Lung, and Blood Institute; as well as by grant U19 AG023122 (A.P.R) from the National Institute on Aging Longevity Consortium. An additional contribution was given from the National Institute of Neurological Disorders and Stroke. Genotyping services for the CHS were provided by the Center for Inherited Disease Research (CIDR). CIDR is fully funded through a federal contract from the National Institutes of Health to The Johns Hopkins University, contract Number N01-HG-65403. Genotyping services for the CHS were also provided by the Johns Hopkins University under federal contract number N01-HV-48195 from the National Heart, Lung, and Blood Institute. The original PRINCE clinical trial was funded by Bristol-Myers Squibb. DNA extraction from PRINCE was funded by Roche, Inc., with additional funds from the Leducq Foundation (Paris, France). P.M.R. is listed as a coinventor on patents held by the Brigham and Women's Hospital that relate to the use of inflammatory biomarkers in cardiovascular disease. ",
year = "2008",
month = may,
day = "9",
doi = "10.1016/j.ajhg.2008.03.017",
language = "English (US)",
volume = "82",
pages = "1193--1201",
journal = "American journal of human genetics",
issn = "0002-9297",
publisher = "Cell Press",
number = "5",
}