Polymorphisms of the HNF1A Gene Encoding Hepatocyte Nuclear Factor-1α are Associated with C-Reactive Protein

Alexander P. Reiner, Mathew J. Barber, Yongtao Guan, Paul M. Ridker, Leslie A. Lange, Daniel I I. Chasman, Jeremy D. Walston, Gregory M. Cooper, Nancy S. Jenny, Mark J. Rieder, J. Peter Durda, Joshua D. Smith, John Novembre, Russell P. Tracy, Jerome I. Rotter, Matthew Stephens, Deborah A. Nickerson, Ronald M. Krauss

Research output: Contribution to journalArticle

Abstract

Data from the Pharmacogenomics and Risk of Cardiovascular Disease (PARC) study and the Cardiovascular Health Study (CHS) provide independent and confirmatory evidence for association between common polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1α and plasma C-reactive protein (CRP) concentration. Analyses with the use of imputation-based methods to combine genotype data from both studies and to test untyped SNPs from the HapMap database identified several SNPs within a 5 kb region of HNF1A intron 1 with the strongest evidence of association with CRP phenotype.

Original languageEnglish (US)
Pages (from-to)1193-1201
Number of pages9
JournalAmerican journal of human genetics
Volume82
Issue number5
DOIs
StatePublished - May 9 2008

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Fingerprint Dive into the research topics of 'Polymorphisms of the HNF1A Gene Encoding Hepatocyte Nuclear Factor-1α are Associated with C-Reactive Protein'. Together they form a unique fingerprint.

  • Cite this

    Reiner, A. P., Barber, M. J., Guan, Y., Ridker, P. M., Lange, L. A., Chasman, DI. I., Walston, J. D., Cooper, G. M., Jenny, N. S., Rieder, M. J., Durda, J. P., Smith, J. D., Novembre, J., Tracy, R. P., Rotter, J. I., Stephens, M., Nickerson, D. A., & Krauss, R. M. (2008). Polymorphisms of the HNF1A Gene Encoding Hepatocyte Nuclear Factor-1α are Associated with C-Reactive Protein. American journal of human genetics, 82(5), 1193-1201. https://doi.org/10.1016/j.ajhg.2008.03.017