Polymorphisms of the cytomegalovirus (CMV)-encoded tumor necrosis factor-α and β-chemokine receptors in congenital CMV disease

Ravit Boger, Rodney E. Willoughby, Robert F. Pass, Jianchao Zong, Won Jong Jang, Donald Alcendor, Gary Selwyn Hayward

Research output: Contribution to journalArticle

Abstract

Some congenital cytomegalovirus (CMV) infections lead to neonatal disease, whereas others have no associated sequelae. To explore a possible role for viral genes as determinants of virulence, portions of the UL144 tumor necrosis factor (TNF)-α-like receptor gene, the US28 β-chemokine receptor gene, and the UL55 envelope glycoprotein B gene from 33 patients with congenital CMV infection were sequenced. Three major UL144 subtypes (A, B, and C) and 2 recombinants (A/C and A/B) were detected. Infection with the least common UL144 subtypes (A, C, A/C, and A/B) was associated with unfavorable disease outcome (P = .04). There was no association between specific subtypes of the US28 and UL55 genes and outcome (P = .864 and P = .765, respectively). Multiple genotypes (implying multiple infections) were detected in tissues from 8 of 10 autopsies. Therefore, polymorphism in the CMV-encoded TNF-α-like receptor appears to be associated with congenital CMV disease. Other CMV polymorphisms should be further evaluated for potential relevance to neonatal infection, transplantation, and acquired immunodeficiency syndrome-associated CMV diseases.

Original languageEnglish (US)
Pages (from-to)1057-1064
Number of pages8
JournalJournal of Infectious Diseases
Volume186
Issue number8
DOIs
Publication statusPublished - Oct 15 2002

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ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

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