TY - JOUR
T1 - Polymorphisms of the cytomegalovirus (CMV)-encoded tumor necrosis factor-α and β-chemokine receptors in congenital CMV disease
AU - Arav-Boger, Ravit
AU - Willoughby, Rodney E.
AU - Pass, Robert F.
AU - Zong, Jian Chao
AU - Jang, Won Jong
AU - Alcendor, Donald
AU - Hayward, Gary S.
PY - 2002/10/15
Y1 - 2002/10/15
N2 - Some congenital cytomegalovirus (CMV) infections lead to neonatal disease, whereas others have no associated sequelae. To explore a possible role for viral genes as determinants of virulence, portions of the UL144 tumor necrosis factor (TNF)-α-like receptor gene, the US28 β-chemokine receptor gene, and the UL55 envelope glycoprotein B gene from 33 patients with congenital CMV infection were sequenced. Three major UL144 subtypes (A, B, and C) and 2 recombinants (A/C and A/B) were detected. Infection with the least common UL144 subtypes (A, C, A/C, and A/B) was associated with unfavorable disease outcome (P = .04). There was no association between specific subtypes of the US28 and UL55 genes and outcome (P = .864 and P = .765, respectively). Multiple genotypes (implying multiple infections) were detected in tissues from 8 of 10 autopsies. Therefore, polymorphism in the CMV-encoded TNF-α-like receptor appears to be associated with congenital CMV disease. Other CMV polymorphisms should be further evaluated for potential relevance to neonatal infection, transplantation, and acquired immunodeficiency syndrome-associated CMV diseases.
AB - Some congenital cytomegalovirus (CMV) infections lead to neonatal disease, whereas others have no associated sequelae. To explore a possible role for viral genes as determinants of virulence, portions of the UL144 tumor necrosis factor (TNF)-α-like receptor gene, the US28 β-chemokine receptor gene, and the UL55 envelope glycoprotein B gene from 33 patients with congenital CMV infection were sequenced. Three major UL144 subtypes (A, B, and C) and 2 recombinants (A/C and A/B) were detected. Infection with the least common UL144 subtypes (A, C, A/C, and A/B) was associated with unfavorable disease outcome (P = .04). There was no association between specific subtypes of the US28 and UL55 genes and outcome (P = .864 and P = .765, respectively). Multiple genotypes (implying multiple infections) were detected in tissues from 8 of 10 autopsies. Therefore, polymorphism in the CMV-encoded TNF-α-like receptor appears to be associated with congenital CMV disease. Other CMV polymorphisms should be further evaluated for potential relevance to neonatal infection, transplantation, and acquired immunodeficiency syndrome-associated CMV diseases.
UR - http://www.scopus.com/inward/record.url?scp=0037108926&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037108926&partnerID=8YFLogxK
U2 - 10.1086/344238
DO - 10.1086/344238
M3 - Article
C2 - 12355354
AN - SCOPUS:0037108926
SN - 0022-1899
VL - 186
SP - 1057
EP - 1064
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 8
ER -