Polymorphisms of dopamine receptor and transporter genes and hallucinations in Parkinson's disease

Jian Wang; Chunying Zhao; Biao Chen; Zhuo Lin Liu

doi:10.1016/j.neulet.2003.11.006

Polymorphisms of dopamine receptor and transporter genes and hallucinations in Parkinson's disease

Jian Wang, Chunying Zhao, Biao Chen, Zhuo Lin Liu

School of Medicine

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

The authors conducted a case-control study of Parkinson's disease patients with and without visual hallucinations to investigate associations of the polymorphisms of the dopamine receptors D2 32806 C>T (Taq1A), D3 Ser ₉Gly and Msp1, D5 978T>C and dopamine transporter 3′-UTR 40 bp VNTR with visual hallucinations in Parkinson's disease. No significant differences were found between hallucinators and non-hallucinators in either the genotypic or allelic distributions. Our data suggest that the loci investigated here are not associated with the visual hallucinogenesis in Parkinson's disease.

Original language	English (US)
Pages (from-to)	193-196
Number of pages	4
Journal	Neuroscience Letters
Volume	355
Issue number	3
DOIs	https://doi.org/10.1016/j.neulet.2003.11.006
State	Published - Jan 30 2004

Keywords

Dopamine
Gene polymorphism
Hallucination
Parkinson's disease
Receptor
Transporter

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neulet.2003.11.006

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title = "Polymorphisms of dopamine receptor and transporter genes and hallucinations in Parkinson's disease",

abstract = "The authors conducted a case-control study of Parkinson's disease patients with and without visual hallucinations to investigate associations of the polymorphisms of the dopamine receptors D2 32806 C>T (Taq1A), D3 Ser 9Gly and Msp1, D5 978T>C and dopamine transporter 3′-UTR 40 bp VNTR with visual hallucinations in Parkinson's disease. No significant differences were found between hallucinators and non-hallucinators in either the genotypic or allelic distributions. Our data suggest that the loci investigated here are not associated with the visual hallucinogenesis in Parkinson's disease.",

keywords = "Dopamine, Gene polymorphism, Hallucination, Parkinson's disease, Receptor, Transporter",

author = "Jian Wang and Chunying Zhao and Biao Chen and Liu, {Zhuo Lin}",

note = "Funding Information: The authors thank all the subjects who participated in this study. They also thank Associate Professors Jinru Li and Yonghui Pan and Drs Enxiang Tao, Ming Shao, Junhui Zhang, Ling Chen, Yi Zhu, and Yanming Xu for their clinical assistance, and Xibang Pan, Xilin Lu, and Yanmei Si for their technical assistance. They also thank Dr L. Idias for revision of the English. This work was supported in part by the Postdoctoral Science Foundation of China (J.W.), and the National Natural Science Foundation of China (J.W.).",

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doi = "10.1016/j.neulet.2003.11.006",

language = "English (US)",

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T1 - Polymorphisms of dopamine receptor and transporter genes and hallucinations in Parkinson's disease

AU - Wang, Jian

AU - Zhao, Chunying

AU - Chen, Biao

AU - Liu, Zhuo Lin

N1 - Funding Information: The authors thank all the subjects who participated in this study. They also thank Associate Professors Jinru Li and Yonghui Pan and Drs Enxiang Tao, Ming Shao, Junhui Zhang, Ling Chen, Yi Zhu, and Yanming Xu for their clinical assistance, and Xibang Pan, Xilin Lu, and Yanmei Si for their technical assistance. They also thank Dr L. Idias for revision of the English. This work was supported in part by the Postdoctoral Science Foundation of China (J.W.), and the National Natural Science Foundation of China (J.W.).

PY - 2004/1/30

Y1 - 2004/1/30

N2 - The authors conducted a case-control study of Parkinson's disease patients with and without visual hallucinations to investigate associations of the polymorphisms of the dopamine receptors D2 32806 C>T (Taq1A), D3 Ser 9Gly and Msp1, D5 978T>C and dopamine transporter 3′-UTR 40 bp VNTR with visual hallucinations in Parkinson's disease. No significant differences were found between hallucinators and non-hallucinators in either the genotypic or allelic distributions. Our data suggest that the loci investigated here are not associated with the visual hallucinogenesis in Parkinson's disease.

AB - The authors conducted a case-control study of Parkinson's disease patients with and without visual hallucinations to investigate associations of the polymorphisms of the dopamine receptors D2 32806 C>T (Taq1A), D3 Ser 9Gly and Msp1, D5 978T>C and dopamine transporter 3′-UTR 40 bp VNTR with visual hallucinations in Parkinson's disease. No significant differences were found between hallucinators and non-hallucinators in either the genotypic or allelic distributions. Our data suggest that the loci investigated here are not associated with the visual hallucinogenesis in Parkinson's disease.

KW - Dopamine

KW - Gene polymorphism

KW - Hallucination

KW - Parkinson's disease

KW - Receptor

KW - Transporter

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VL - 355

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EP - 196

JO - Neuroscience Letters

JF - Neuroscience Letters

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ER -

Polymorphisms of dopamine receptor and transporter genes and hallucinations in Parkinson's disease

Abstract

Keywords

ASJC Scopus subject areas

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