TY - JOUR
T1 - Polymorphisms of an innate immune gene, toll-like receptor 4, and aggressive prostate cancer risk
T2 - A systematic review and meta-analysis
AU - Weng, Pei Hsuan
AU - Huang, Yi Ling
AU - Page, John H.
AU - Chen, Jen Hau
AU - Xu, Jianfeng
AU - Koutros, Stella
AU - Berndt, Sonja
AU - Chanock, Stephen
AU - Yeager, Meredith
AU - Witte, John S.
AU - Eeles, Rosalind A.
AU - Easton, Douglas F.
AU - Neall, David E.
AU - Donovanl, Jenny
AU - Hamdyl, Freddie C.
AU - Muir, Kenneth R.
AU - Giles, Graham
AU - Severi, Gianluca
AU - Smith, Jeffrey R.
AU - Balistreri, Carmela R.
AU - Shui, Irene M.
AU - Chen, Yen Ching
N1 - Publisher Copyright:
© 2014 Weng et al.
PY - 2014/10/31
Y1 - 2014/10/31
N2 - Background: Toll-like receptor 4 (TLR4) is one of the best known TLR members expressed on the surface of several leukocytes and tissue cells and has a key function in detecting pathogen and danger-associated molecular patterns. The role of TLR4 in the pathophysiology of several age-related diseases is also well recognized, such as prostate cancer (PCa). TLR4 polymorphisms have been related to PCa risk, but the relationship between TLR4 genotypes and aggressive PCa risk has not been evaluated by any systematic reviews.Methods: We performed a systematic review and meta-analysis of candidate-gene and genome-wide association studies analyzing this relationship and included only white population. Considering appropriate criteria, only nine studies were analyzed in the meta-analysis, including 3,937 aggressive PCa and 7,382 controls.Results: Using random effects model, no significant association was found in the ten TLR4 SNPs reported by at least four included studies under any inheritance model (rs2737191, rs1927914, rs10759932, rs1927911, rs11536879, rs2149356, rs4986790, rs11536889, rs7873784, and rs1554973). Pooled estimates from another ten TLR4 SNPs reported by three studies also showed no significant association (rs10759930, rs10116253, rs11536869, rs5030717, rs4986791, rs11536897, rs1927906, rs913930, rs1927905, and rs7045953). Meta-regression revealed that study type was not a significant source of between-study heterogeneity.Conclusions: TLR4 polymorphisms were not significantly associated with the risk of aggressive PCa.
AB - Background: Toll-like receptor 4 (TLR4) is one of the best known TLR members expressed on the surface of several leukocytes and tissue cells and has a key function in detecting pathogen and danger-associated molecular patterns. The role of TLR4 in the pathophysiology of several age-related diseases is also well recognized, such as prostate cancer (PCa). TLR4 polymorphisms have been related to PCa risk, but the relationship between TLR4 genotypes and aggressive PCa risk has not been evaluated by any systematic reviews.Methods: We performed a systematic review and meta-analysis of candidate-gene and genome-wide association studies analyzing this relationship and included only white population. Considering appropriate criteria, only nine studies were analyzed in the meta-analysis, including 3,937 aggressive PCa and 7,382 controls.Results: Using random effects model, no significant association was found in the ten TLR4 SNPs reported by at least four included studies under any inheritance model (rs2737191, rs1927914, rs10759932, rs1927911, rs11536879, rs2149356, rs4986790, rs11536889, rs7873784, and rs1554973). Pooled estimates from another ten TLR4 SNPs reported by three studies also showed no significant association (rs10759930, rs10116253, rs11536869, rs5030717, rs4986791, rs11536897, rs1927906, rs913930, rs1927905, and rs7045953). Meta-regression revealed that study type was not a significant source of between-study heterogeneity.Conclusions: TLR4 polymorphisms were not significantly associated with the risk of aggressive PCa.
UR - http://www.scopus.com/inward/record.url?scp=84910060445&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84910060445&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0110569
DO - 10.1371/journal.pone.0110569
M3 - Review article
C2 - 25360682
AN - SCOPUS:84910060445
SN - 1932-6203
VL - 9
JO - PloS one
JF - PloS one
IS - 10
M1 - e110569
ER -