Polymorphisms in JAK/STAT signaling pathway genes and risk of non-Hodgkin lymphoma

Yingtai Chen, Qing Lan, Tongzhang Zheng, Nan Zhao, Theodore R. Holford, Catherine Lerro, Min Dai, Huang Huang, Jiaxin Liang, Shuangge Ma, Brian Leaderer, Peter Boyle, Stephen Chanock, Nathaniel Rothman, Yawei Zhang

Research output: Contribution to journalArticlepeer-review

Abstract

Impaired function of Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway genes leads to immunodeficiency and various hematopoietic disorders. We evaluated the association between genetic polymorphisms (SNPs) in 12 JAK/STAT pathway genes (JAK3, STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6, SCOS1, SCOS2, SCOS3, and SCOS4) and NHL risk in a population-based case-control study of Connecticut women. We identified three SNPs in STAT3 (rs12949918 and rs6503695) and STAT4 (rs932169) associated with NHL risk after adjustment for multiple comparison. Our results suggest that genetic variation in JAK/STAT pathway genes may play a role in lymphomagenesis and warrants further investigation.

Original languageEnglish (US)
Pages (from-to)1120-1124
Number of pages5
JournalLeukemia Research
Volume37
Issue number9
DOIs
StatePublished - Sep 2013

Keywords

  • Case-control study
  • JAK/STAT signaling pathway
  • Non-Hodgkin lymphoma
  • Polymorphism

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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