Polymorphisms in JAK/STAT signaling pathway genes and risk of non-Hodgkin lymphoma

Yingtai Chen, Qing Lan, Tongzhang Zheng, Nan Zhao, Theodore R. Holford, Catherine Lerro, Min Dai, Huang Huang, Jiaxin Liang, Shuangge Ma, Brian Leaderer, Peter Boyle, Stephen Chanock, Nathaniel Rothman, Yawei Zhang

Research output: Contribution to journalArticle

Abstract

Impaired function of Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway genes leads to immunodeficiency and various hematopoietic disorders. We evaluated the association between genetic polymorphisms (SNPs) in 12 JAK/STAT pathway genes (JAK3, STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6, SCOS1, SCOS2, SCOS3, and SCOS4) and NHL risk in a population-based case-control study of Connecticut women. We identified three SNPs in STAT3 (rs12949918 and rs6503695) and STAT4 (rs932169) associated with NHL risk after adjustment for multiple comparison. Our results suggest that genetic variation in JAK/STAT pathway genes may play a role in lymphomagenesis and warrants further investigation.

Original languageEnglish (US)
Pages (from-to)1120-1124
Number of pages5
JournalLeukemia Research
Volume37
Issue number9
DOIs
StatePublished - Sep 2013
Externally publishedYes

Fingerprint

Janus Kinases
Transducers
Non-Hodgkin's Lymphoma
Single Nucleotide Polymorphism
Genes
Risk Adjustment
Genetic Polymorphisms
Case-Control Studies
Population

Keywords

  • Case-control study
  • JAK/STAT signaling pathway
  • Non-Hodgkin lymphoma
  • Polymorphism

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

Chen, Y., Lan, Q., Zheng, T., Zhao, N., Holford, T. R., Lerro, C., ... Zhang, Y. (2013). Polymorphisms in JAK/STAT signaling pathway genes and risk of non-Hodgkin lymphoma. Leukemia Research, 37(9), 1120-1124. https://doi.org/10.1016/j.leukres.2013.05.003

Polymorphisms in JAK/STAT signaling pathway genes and risk of non-Hodgkin lymphoma. / Chen, Yingtai; Lan, Qing; Zheng, Tongzhang; Zhao, Nan; Holford, Theodore R.; Lerro, Catherine; Dai, Min; Huang, Huang; Liang, Jiaxin; Ma, Shuangge; Leaderer, Brian; Boyle, Peter; Chanock, Stephen; Rothman, Nathaniel; Zhang, Yawei.

In: Leukemia Research, Vol. 37, No. 9, 09.2013, p. 1120-1124.

Research output: Contribution to journalArticle

Chen, Y, Lan, Q, Zheng, T, Zhao, N, Holford, TR, Lerro, C, Dai, M, Huang, H, Liang, J, Ma, S, Leaderer, B, Boyle, P, Chanock, S, Rothman, N & Zhang, Y 2013, 'Polymorphisms in JAK/STAT signaling pathway genes and risk of non-Hodgkin lymphoma', Leukemia Research, vol. 37, no. 9, pp. 1120-1124. https://doi.org/10.1016/j.leukres.2013.05.003
Chen, Yingtai ; Lan, Qing ; Zheng, Tongzhang ; Zhao, Nan ; Holford, Theodore R. ; Lerro, Catherine ; Dai, Min ; Huang, Huang ; Liang, Jiaxin ; Ma, Shuangge ; Leaderer, Brian ; Boyle, Peter ; Chanock, Stephen ; Rothman, Nathaniel ; Zhang, Yawei. / Polymorphisms in JAK/STAT signaling pathway genes and risk of non-Hodgkin lymphoma. In: Leukemia Research. 2013 ; Vol. 37, No. 9. pp. 1120-1124.
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