Polymorphisms in inflammatory cytokines and fcγ receptors in childhood chronic immune thrombocytopenic purpura: A pilot study

Charles B. Foster, Shaoxian Zhu, Hans Christian Erichsen, Thomas Lehrnbecher, Elizabeth S. Hart, Eunhwa Choi, Steven Stein, Michael W. Smith, Seth M. Steinberg, Paul Imbach, Thomas Kühne, Stephen J. Chanock

Research output: Contribution to journalArticlepeer-review

Abstract

Inflammatory cytokines and low-affinity Fcγ receptor (FcγR) polymorphisms were investigated in 37 children with chronic immune thrombocytopenic purpura (cITP) and 218 controls. Genotype analysis included common variants in the regulatory regions of cytokines, TNF, LTA, IL1RN, IL1A, IL1B, IL4, IL6 and IL10, and structural variants of the low affinity FcγRs, FCGR2A, FCGR3A and FCGR3B. Associations were observed for TNF (P = 0.0032), LTA (P = 0.019), FCGR3A (P = 0.038) and FCGR3B (P = 0.0034). Two combinations of genotypes (TNF and FCGR3A; P = 0.0003, and LTA and FCGR3B; P = 0.011) were significantly associated with cITP. These results provide preliminary evidence that variant genotypes of FcγRs and cytokines contribute to cITP pathogenesis.

Original languageEnglish (US)
Pages (from-to)596-599
Number of pages4
JournalBritish journal of haematology
Volume113
Issue number3
DOIs
StatePublished - 2001

Keywords

  • Chronic immune thrombocytopenic purpura
  • Cytokines
  • Fc gamma receptors
  • Genetic associations

ASJC Scopus subject areas

  • Hematology

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