Polymorphisms in inflammatory cytokines and fcγ receptors in childhood chronic immune thrombocytopenic purpura: A pilot study

Charles B. Foster; Shaoxian Zhu; Hans Christian Erichsen; Thomas Lehrnbecher; Elizabeth S. Hart; Eunhwa Choi; Steven Stein; Michael W. Smith; Seth M. Steinberg; Paul Imbach; Thomas Kühne; Stephen J. Chanock

doi:10.1046/j.1365-2141.2001.02807.x

Polymorphisms in inflammatory cytokines and fcγ receptors in childhood chronic immune thrombocytopenic purpura: A pilot study

Charles B. Foster, Shaoxian Zhu, Hans Christian Erichsen, Thomas Lehrnbecher, Elizabeth S. Hart, Eunhwa Choi, Steven Stein, Michael W. Smith, Seth M. Steinberg, Paul Imbach, Thomas Kühne, Stephen J. Chanock

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75 Scopus citations

Abstract

Inflammatory cytokines and low-affinity Fcγ receptor (FcγR) polymorphisms were investigated in 37 children with chronic immune thrombocytopenic purpura (cITP) and 218 controls. Genotype analysis included common variants in the regulatory regions of cytokines, TNF, LTA, IL1RN, IL1A, IL1B, IL4, IL6 and IL10, and structural variants of the low affinity FcγRs, FCGR2A, FCGR3A and FCGR3B. Associations were observed for TNF (P = 0.0032), LTA (P = 0.019), FCGR3A (P = 0.038) and FCGR3B (P = 0.0034). Two combinations of genotypes (TNF and FCGR3A; P = 0.0003, and LTA and FCGR3B; P = 0.011) were significantly associated with cITP. These results provide preliminary evidence that variant genotypes of FcγRs and cytokines contribute to cITP pathogenesis.

Original language	English (US)
Pages (from-to)	596-599
Number of pages	4
Journal	British journal of haematology
Volume	113
Issue number	3
DOIs	https://doi.org/10.1046/j.1365-2141.2001.02807.x
State	Published - 2001
Externally published	Yes

Keywords

Chronic immune thrombocytopenic purpura
Cytokines
Fc gamma receptors
Genetic associations

ASJC Scopus subject areas

Hematology

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10.1046/j.1365-2141.2001.02807.x

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Foster, C. B., Zhu, S., Erichsen, H. C., Lehrnbecher, T., Hart, E. S., Choi, E., Stein, S., Smith, M. W., Steinberg, S. M., Imbach, P., Kühne, T., & Chanock, S. J. (2001). Polymorphisms in inflammatory cytokines and fcγ receptors in childhood chronic immune thrombocytopenic purpura: A pilot study. British journal of haematology, 113(3), 596-599. https://doi.org/10.1046/j.1365-2141.2001.02807.x

Foster, CB, Zhu, S, Erichsen, HC, Lehrnbecher, T, Hart, ES, Choi, E, Stein, S, Smith, MW, Steinberg, SM, Imbach, P, Kühne, T & Chanock, SJ 2001, 'Polymorphisms in inflammatory cytokines and fcγ receptors in childhood chronic immune thrombocytopenic purpura: A pilot study', British journal of haematology, vol. 113, no. 3, pp. 596-599. https://doi.org/10.1046/j.1365-2141.2001.02807.x

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title = "Polymorphisms in inflammatory cytokines and fcγ receptors in childhood chronic immune thrombocytopenic purpura: A pilot study",

abstract = "Inflammatory cytokines and low-affinity Fcγ receptor (FcγR) polymorphisms were investigated in 37 children with chronic immune thrombocytopenic purpura (cITP) and 218 controls. Genotype analysis included common variants in the regulatory regions of cytokines, TNF, LTA, IL1RN, IL1A, IL1B, IL4, IL6 and IL10, and structural variants of the low affinity FcγRs, FCGR2A, FCGR3A and FCGR3B. Associations were observed for TNF (P = 0.0032), LTA (P = 0.019), FCGR3A (P = 0.038) and FCGR3B (P = 0.0034). Two combinations of genotypes (TNF and FCGR3A; P = 0.0003, and LTA and FCGR3B; P = 0.011) were significantly associated with cITP. These results provide preliminary evidence that variant genotypes of FcγRs and cytokines contribute to cITP pathogenesis.",

keywords = "Chronic immune thrombocytopenic purpura, Cytokines, Fc gamma receptors, Genetic associations",

author = "Foster, {Charles B.} and Shaoxian Zhu and Erichsen, {Hans Christian} and Thomas Lehrnbecher and Hart, {Elizabeth S.} and Eunhwa Choi and Steven Stein and Smith, {Michael W.} and Steinberg, {Seth M.} and Paul Imbach and Thomas K{\"u}hne and Chanock, {Stephen J.}",

year = "2001",

doi = "10.1046/j.1365-2141.2001.02807.x",

language = "English (US)",

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AU - Foster, Charles B.

AU - Zhu, Shaoxian

AU - Erichsen, Hans Christian

AU - Lehrnbecher, Thomas

AU - Hart, Elizabeth S.

AU - Choi, Eunhwa

AU - Stein, Steven

AU - Smith, Michael W.

AU - Steinberg, Seth M.

AU - Imbach, Paul

AU - Kühne, Thomas

AU - Chanock, Stephen J.

PY - 2001

Y1 - 2001

N2 - Inflammatory cytokines and low-affinity Fcγ receptor (FcγR) polymorphisms were investigated in 37 children with chronic immune thrombocytopenic purpura (cITP) and 218 controls. Genotype analysis included common variants in the regulatory regions of cytokines, TNF, LTA, IL1RN, IL1A, IL1B, IL4, IL6 and IL10, and structural variants of the low affinity FcγRs, FCGR2A, FCGR3A and FCGR3B. Associations were observed for TNF (P = 0.0032), LTA (P = 0.019), FCGR3A (P = 0.038) and FCGR3B (P = 0.0034). Two combinations of genotypes (TNF and FCGR3A; P = 0.0003, and LTA and FCGR3B; P = 0.011) were significantly associated with cITP. These results provide preliminary evidence that variant genotypes of FcγRs and cytokines contribute to cITP pathogenesis.

AB - Inflammatory cytokines and low-affinity Fcγ receptor (FcγR) polymorphisms were investigated in 37 children with chronic immune thrombocytopenic purpura (cITP) and 218 controls. Genotype analysis included common variants in the regulatory regions of cytokines, TNF, LTA, IL1RN, IL1A, IL1B, IL4, IL6 and IL10, and structural variants of the low affinity FcγRs, FCGR2A, FCGR3A and FCGR3B. Associations were observed for TNF (P = 0.0032), LTA (P = 0.019), FCGR3A (P = 0.038) and FCGR3B (P = 0.0034). Two combinations of genotypes (TNF and FCGR3A; P = 0.0003, and LTA and FCGR3B; P = 0.011) were significantly associated with cITP. These results provide preliminary evidence that variant genotypes of FcγRs and cytokines contribute to cITP pathogenesis.

KW - Chronic immune thrombocytopenic purpura

KW - Cytokines

KW - Fc gamma receptors

KW - Genetic associations

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Polymorphisms in inflammatory cytokines and fcγ receptors in childhood chronic immune thrombocytopenic purpura: A pilot study

Abstract

Keywords

ASJC Scopus subject areas

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