Polymorphisms in chemokine receptor genes and susceptibility to Kawasaki disease

W. B. Breunis, M. H. Biezeveld, J. Geissler, I. M. Kuipers, J. Lam, J. Ottenkamp, A. Hutchinson, R. Welch, S. J. Chanock, T. W. Kuijpers

Research output: Contribution to journalArticle

Abstract

Kawasaki disease (KD) is an acute vasculitis occurring in young children. Its aetiology is unknown, but an infectious agent is assumed. Increased levels of proinflammatory cytokines and chemokines have been reported in KD. Genetic variation in these genes and the receptors for these genes could influence the regulation of cytokines and chemokines. In a case-control study of 170 Dutch Caucasian KD patients and 300 healthy Dutch Caucasian controls, common genetic variants in chemokine receptor genes CCR3, CCR2, CCR5, CX3CR1, CXCR1 and CXCR2 were analysed. Of the eight studied single nucleotide polymorphisms (SNPs) in the CCR3-CCR2-CCR5 gene cluster, four showed a significant association with susceptibility to KD. Moreover the CCR5-Δ32 was observed with an allele frequency of 10.7% in the control population compared to 6.5% in the KD patients (P = 0.04). Two haplotypes of the CCR3-CCR2-CCR5 gene-cluster appear to be at risk haplotypes for KD and one a protective haplotype. No association was observed with the studied SNPs in CX3CR1, CXCR1 and CXCR2. In conclusion, in a Dutch cohort of KD patients an association of KD occurrence with common genetic variants in the chemokine receptor gene-cluster CCR3-CCR2-CCR5 was observed.

Original languageEnglish (US)
Pages (from-to)83-90
Number of pages8
JournalClinical and Experimental Immunology
Volume150
Issue number1
DOIs
StatePublished - Oct 1 2007

Keywords

  • Chemokine receptor
  • Chemokines
  • Kawasaki disease
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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  • Cite this

    Breunis, W. B., Biezeveld, M. H., Geissler, J., Kuipers, I. M., Lam, J., Ottenkamp, J., Hutchinson, A., Welch, R., Chanock, S. J., & Kuijpers, T. W. (2007). Polymorphisms in chemokine receptor genes and susceptibility to Kawasaki disease. Clinical and Experimental Immunology, 150(1), 83-90. https://doi.org/10.1111/j.1365-2249.2007.03457.x