Polymorphism of the thymidylate synthase gene and thymidylate synthase levels in colon cancer cell lines and different tissues of colorectal cancer patients

R. Mauritz; I. J. Beumer; S. Marsh; H. L. McLeod; K. Smid; C. J. Van Groeningen; H. M. Pinedo; G. J. Peters

doi:10.1081/NCN-200027634

Polymorphism of the thymidylate synthase gene and thymidylate synthase levels in colon cancer cell lines and different tissues of colorectal cancer patients

R. Mauritz, I. J. Beumer, S. Marsh, H. L. McLeod, K. Smid, C. J. Van Groeningen, H. M. Pinedo, G. J. Peters

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

In a panel of 18 colon cancer cell lines we found that the thymidylate synthase (TS) genotype was related to TS enzyme activity, but not to TS protein and mRNA levels. In addition, no relation with drug sensitivity was observed. TS genotyping of different tissues from 78 colorectal cancer patients revealed a high level of homology in polymorphic status between normal and malignant tissues and the heterozygous genotype to be the most frequent.

Original language	English (US)
Pages (from-to)	1381-1384
Number of pages	4
Journal	Nucleosides, Nucleotides and Nucleic Acids
Volume	23
Issue number	8-9
DOIs	https://doi.org/10.1081/NCN-200027634
State	Published - 2004
Externally published	Yes

Keywords

5-Fluorouracil
Colorectal carcinoma
Polymorphism
Thymidylate synthase

ASJC Scopus subject areas

Genetics
Biochemistry

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10.1081/NCN-200027634

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Mauritz, R., Beumer, I. J., Marsh, S., McLeod, H. L., Smid, K., Van Groeningen, C. J., Pinedo, H. M., & Peters, G. J. (2004). Polymorphism of the thymidylate synthase gene and thymidylate synthase levels in colon cancer cell lines and different tissues of colorectal cancer patients. Nucleosides, Nucleotides and Nucleic Acids, 23(8-9), 1381-1384. https://doi.org/10.1081/NCN-200027634

Mauritz, R, Beumer, IJ, Marsh, S, McLeod, HL, Smid, K, Van Groeningen, CJ, Pinedo, HM & Peters, GJ 2004, 'Polymorphism of the thymidylate synthase gene and thymidylate synthase levels in colon cancer cell lines and different tissues of colorectal cancer patients', Nucleosides, Nucleotides and Nucleic Acids, vol. 23, no. 8-9, pp. 1381-1384. https://doi.org/10.1081/NCN-200027634

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AU - Mauritz, R.

AU - Beumer, I. J.

AU - Marsh, S.

AU - McLeod, H. L.

AU - Smid, K.

AU - Van Groeningen, C. J.

AU - Pinedo, H. M.

AU - Peters, G. J.

PY - 2004

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AB - In a panel of 18 colon cancer cell lines we found that the thymidylate synthase (TS) genotype was related to TS enzyme activity, but not to TS protein and mRNA levels. In addition, no relation with drug sensitivity was observed. TS genotyping of different tissues from 78 colorectal cancer patients revealed a high level of homology in polymorphic status between normal and malignant tissues and the heterozygous genotype to be the most frequent.

KW - 5-Fluorouracil

KW - Colorectal carcinoma

KW - Polymorphism

KW - Thymidylate synthase

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Polymorphism of the thymidylate synthase gene and thymidylate synthase levels in colon cancer cell lines and different tissues of colorectal cancer patients

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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