Abstract
In a panel of 18 colon cancer cell lines we found that the thymidylate synthase (TS) genotype was related to TS enzyme activity, but not to TS protein and mRNA levels. In addition, no relation with drug sensitivity was observed. TS genotyping of different tissues from 78 colorectal cancer patients revealed a high level of homology in polymorphic status between normal and malignant tissues and the heterozygous genotype to be the most frequent.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1381-1384 |
| Number of pages | 4 |
| Journal | Nucleosides, Nucleotides and Nucleic Acids |
| Volume | 23 |
| Issue number | 8-9 |
| DOIs | |
| State | Published - 2004 |
| Externally published | Yes |
Keywords
- 5-Fluorouracil
- Colorectal carcinoma
- Polymorphism
- Thymidylate synthase
ASJC Scopus subject areas
- Genetics
- Biochemistry
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Cite this
Mauritz, R., Beumer, I. J., Marsh, S., McLeod, H. L., Smid, K., Van Groeningen, C. J., Pinedo, H. M., & Peters, G. J. (2004). Polymorphism of the thymidylate synthase gene and thymidylate synthase levels in colon cancer cell lines and different tissues of colorectal cancer patients. Nucleosides, Nucleotides and Nucleic Acids, 23(8-9), 1381-1384. https://doi.org/10.1081/NCN-200027634