Polymorphism of DCDC2 reveals differences in cortical morphology of healthy individuals-A preliminary Voxel based morphometry study

Shashwath A. Meda, Joel Gelernter, Jeffrey R. Gruen, Vince D. Calhoun, Haiying Meng, Natalie A. Cope, Godfrey D. Pearlson

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Objective: The purpose of this investigation was to determine whether there is an association between the putative reading disability (RD) susceptibility gene Doublecortin Domain Containing 2 (DCDC2), and gray matter (GM) distribution in the brain, in a sample of healthy control individuals. Method: Fifty-six control subjects were genotyped for an RD-associated deletion in intron 2 of DCDC2. Voxel based morphometry (VBM) was used to examine structural magnetic resonance imaging (MRI) scans to assess GM differences between the two groups. Results: Individuals heterozygous for the deletion exhibited significantly higher GM volumes in reading/language and symbol-decoding related brain regions including superior, medial and inferior temporal, fusiform, hippocampal/parahippocampal, inferior occipito-parietal, inferior and middle frontal gyri, especially in the left hemisphere. GM values correlated with published data on regional DCDC2 expression in a lateralized manner. Conclusions: These data suggest a role for DCDC2 in GM distribution in language-related brain regions in healthy individuals.

    Original languageEnglish (US)
    Pages (from-to)21-26
    Number of pages6
    JournalBrain Imaging and Behavior
    Volume2
    Issue number1
    DOIs
    StatePublished - Mar 1 2008

    Keywords

    • Dyslexia
    • Language
    • Polymorphism
    • Structural imaging
    • VBM

    ASJC Scopus subject areas

    • Radiology Nuclear Medicine and imaging
    • Neurology
    • Cognitive Neuroscience
    • Clinical Neurology
    • Cellular and Molecular Neuroscience
    • Psychiatry and Mental health
    • Behavioral Neuroscience

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