Polymorphism of DCDC2 reveals differences in cortical morphology of healthy individuals-A preliminary Voxel based morphometry study

Shashwath A. Meda, Joel Gelernter, Jeffrey R. Gruen, Vince Daniel Calhoun, Haiying Meng, Natalie A. Cope, Godfrey D. Pearlson

Research output: Contribution to journalArticle

Abstract

Objective: The purpose of this investigation was to determine whether there is an association between the putative reading disability (RD) susceptibility gene Doublecortin Domain Containing 2 (DCDC2), and gray matter (GM) distribution in the brain, in a sample of healthy control individuals. Method: Fifty-six control subjects were genotyped for an RD-associated deletion in intron 2 of DCDC2. Voxel based morphometry (VBM) was used to examine structural magnetic resonance imaging (MRI) scans to assess GM differences between the two groups. Results: Individuals heterozygous for the deletion exhibited significantly higher GM volumes in reading/language and symbol-decoding related brain regions including superior, medial and inferior temporal, fusiform, hippocampal/parahippocampal, inferior occipito-parietal, inferior and middle frontal gyri, especially in the left hemisphere. GM values correlated with published data on regional DCDC2 expression in a lateralized manner. Conclusions: These data suggest a role for DCDC2 in GM distribution in language-related brain regions in healthy individuals.

Original languageEnglish (US)
Pages (from-to)21-26
Number of pages6
JournalBrain Imaging and Behavior
Volume2
Issue number1
DOIs
StatePublished - Mar 2008
Externally publishedYes

Fingerprint

Reading
Brain
Language
Prefrontal Cortex
Introns
Magnetic Resonance Imaging
Gray Matter
Genes

Keywords

  • Dyslexia
  • Language
  • Polymorphism
  • Structural imaging
  • VBM

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Neurology
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience
  • Behavioral Neuroscience
  • Radiology Nuclear Medicine and imaging

Cite this

Polymorphism of DCDC2 reveals differences in cortical morphology of healthy individuals-A preliminary Voxel based morphometry study. / Meda, Shashwath A.; Gelernter, Joel; Gruen, Jeffrey R.; Calhoun, Vince Daniel; Meng, Haiying; Cope, Natalie A.; Pearlson, Godfrey D.

In: Brain Imaging and Behavior, Vol. 2, No. 1, 03.2008, p. 21-26.

Research output: Contribution to journalArticle

Meda, Shashwath A. ; Gelernter, Joel ; Gruen, Jeffrey R. ; Calhoun, Vince Daniel ; Meng, Haiying ; Cope, Natalie A. ; Pearlson, Godfrey D. / Polymorphism of DCDC2 reveals differences in cortical morphology of healthy individuals-A preliminary Voxel based morphometry study. In: Brain Imaging and Behavior. 2008 ; Vol. 2, No. 1. pp. 21-26.
@article{fb9cfc90e59e4b11842fb77beed0f500,
title = "Polymorphism of DCDC2 reveals differences in cortical morphology of healthy individuals-A preliminary Voxel based morphometry study",
abstract = "Objective: The purpose of this investigation was to determine whether there is an association between the putative reading disability (RD) susceptibility gene Doublecortin Domain Containing 2 (DCDC2), and gray matter (GM) distribution in the brain, in a sample of healthy control individuals. Method: Fifty-six control subjects were genotyped for an RD-associated deletion in intron 2 of DCDC2. Voxel based morphometry (VBM) was used to examine structural magnetic resonance imaging (MRI) scans to assess GM differences between the two groups. Results: Individuals heterozygous for the deletion exhibited significantly higher GM volumes in reading/language and symbol-decoding related brain regions including superior, medial and inferior temporal, fusiform, hippocampal/parahippocampal, inferior occipito-parietal, inferior and middle frontal gyri, especially in the left hemisphere. GM values correlated with published data on regional DCDC2 expression in a lateralized manner. Conclusions: These data suggest a role for DCDC2 in GM distribution in language-related brain regions in healthy individuals.",
keywords = "Dyslexia, Language, Polymorphism, Structural imaging, VBM",
author = "Meda, {Shashwath A.} and Joel Gelernter and Gruen, {Jeffrey R.} and Calhoun, {Vince Daniel} and Haiying Meng and Cope, {Natalie A.} and Pearlson, {Godfrey D.}",
year = "2008",
month = "3",
doi = "10.1007/s11682-007-9012-1",
language = "English (US)",
volume = "2",
pages = "21--26",
journal = "Brain Imaging and Behavior",
issn = "1931-7557",
publisher = "Springer New York",
number = "1",

}

TY - JOUR

T1 - Polymorphism of DCDC2 reveals differences in cortical morphology of healthy individuals-A preliminary Voxel based morphometry study

AU - Meda, Shashwath A.

AU - Gelernter, Joel

AU - Gruen, Jeffrey R.

AU - Calhoun, Vince Daniel

AU - Meng, Haiying

AU - Cope, Natalie A.

AU - Pearlson, Godfrey D.

PY - 2008/3

Y1 - 2008/3

N2 - Objective: The purpose of this investigation was to determine whether there is an association between the putative reading disability (RD) susceptibility gene Doublecortin Domain Containing 2 (DCDC2), and gray matter (GM) distribution in the brain, in a sample of healthy control individuals. Method: Fifty-six control subjects were genotyped for an RD-associated deletion in intron 2 of DCDC2. Voxel based morphometry (VBM) was used to examine structural magnetic resonance imaging (MRI) scans to assess GM differences between the two groups. Results: Individuals heterozygous for the deletion exhibited significantly higher GM volumes in reading/language and symbol-decoding related brain regions including superior, medial and inferior temporal, fusiform, hippocampal/parahippocampal, inferior occipito-parietal, inferior and middle frontal gyri, especially in the left hemisphere. GM values correlated with published data on regional DCDC2 expression in a lateralized manner. Conclusions: These data suggest a role for DCDC2 in GM distribution in language-related brain regions in healthy individuals.

AB - Objective: The purpose of this investigation was to determine whether there is an association between the putative reading disability (RD) susceptibility gene Doublecortin Domain Containing 2 (DCDC2), and gray matter (GM) distribution in the brain, in a sample of healthy control individuals. Method: Fifty-six control subjects were genotyped for an RD-associated deletion in intron 2 of DCDC2. Voxel based morphometry (VBM) was used to examine structural magnetic resonance imaging (MRI) scans to assess GM differences between the two groups. Results: Individuals heterozygous for the deletion exhibited significantly higher GM volumes in reading/language and symbol-decoding related brain regions including superior, medial and inferior temporal, fusiform, hippocampal/parahippocampal, inferior occipito-parietal, inferior and middle frontal gyri, especially in the left hemisphere. GM values correlated with published data on regional DCDC2 expression in a lateralized manner. Conclusions: These data suggest a role for DCDC2 in GM distribution in language-related brain regions in healthy individuals.

KW - Dyslexia

KW - Language

KW - Polymorphism

KW - Structural imaging

KW - VBM

UR - http://www.scopus.com/inward/record.url?scp=77949646703&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77949646703&partnerID=8YFLogxK

U2 - 10.1007/s11682-007-9012-1

DO - 10.1007/s11682-007-9012-1

M3 - Article

C2 - 19096528

AN - SCOPUS:77949646703

VL - 2

SP - 21

EP - 26

JO - Brain Imaging and Behavior

JF - Brain Imaging and Behavior

SN - 1931-7557

IS - 1

ER -