Polymorphism in the GALNT1 gene and epithelial ovarian cancer in non-hispanic white women: The Ovarian Cancer Association Consortium

Catherine M. Phelan, Ya Yu Tsai, Ellen L. Goode, Robert A. Vierkant, Brooke L. Fridley, Jonathan Beesley, Xiao Qing Chen, Penelope M. Webb, Stephen Chanock, Daniel W. Cramer, Kirsten Moysich, Robert P. Edwards, Jenny Chang-Claude, Montserrat Garcia-Closas, Hannah Yang, Shan Wang-Gohrke, Rebecca Hein, Adele C. Green, Jolanta Lissowska, Michael E. CarneyGalina Lurie, Lynne R. Wilkens, Roberta B. Ness, Celeste Leigh Pearce, Anna H. Wu, David J. Van Den Berg, Daniel O. Stram, Kathryn L. Terry, David C. Whiteman, Alice S. Whittemore, Richard A. DiCioccio, Valerie McGuire, Jennifer A. Doherty, Mary Anne Rossing, Hoda Anton-Culver, Argyrios Ziogas, Claus Hogdall, Estrid Hogdall, Susanne Krüger Kjaer, Jan Blaakaer, Lydia Quaye, Susan J. Ramus, Ian Jacobs, Honglin Song, Paul D.P. Pharoah, Edwin S. Iversen, Jeffrey R. Marks, Malcolm C. Pike, Simon A. Gayther, Julie M. Cunningham, Marc T. Goodman, Joellen M. Schildkraut, Georgia Chenevix-Trench, Andrew Berchuck, Thomas A. Sellers

Research output: Contribution to journalArticlepeer-review

Abstract

Aberrant glycosylation is a well-described hallmark of cancer. In a previous ovarian cancer case control study that examined polymorphisms in 26 glycosylation-associated genes, we found strong statistical evidence (P = 0.00017) that women who inherited two copies of a single-nucleotide polymorphism in the UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase, GALNT1, had decreased ovarian cancer risk. The current study attempted to replicate this observation. The GALNT1 single-nucleotide polymorphism rs17647532 was genotyped in 6,965 cases and 8,377 controls from 14 studies forming the Ovarian Cancer Association Consortium. The fixed effects estimate per rs17647532 allele was null (odds ratio, 0.99; 95% confidence interval, 0.92-1.07). When a recessive model was fit, the results were unchanged. Test for hetero geneity of the odds ratios revealed consistency across the 14 replication sites but significant differences compared with the original study population (P = 0.03). This study underscores the need for replication of putative findings in genetic association studies.

Original languageEnglish (US)
Pages (from-to)600-604
Number of pages5
JournalCancer Epidemiology Biomarkers and Prevention
Volume19
Issue number2
DOIs
StatePublished - Feb 2010

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

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