Polymers to treat brain tumours

Research output: Contribution to journalArticlepeer-review

Abstract

Brain tumours are difficult to treat by conventional methods. A biodegradable polymer, poly-[bis(p-carboxyphenoxy) propane sebacic acid] with a nitrosourea, carmustine, has been demonstrated to be biocompatible in the brains of experimental animals and to release drugs in a predictable sustained manner. Carmustine impregnated in polymers appears to be more effective than when delivered by standard methods. A Phase I clinical study has demonstrated the safety of this approach in treating brain tumours and a Phase III placebo-controlled study is currently underway. Other applications of the polymer in the treatment of brain diseases are discussed.

Original languageEnglish (US)
Pages (from-to)699-701
Number of pages3
JournalBiomaterials
Volume11
Issue number9
DOIs
StatePublished - Nov 1990

Keywords

  • Drug delivery
  • biodegradation
  • carmustine
  • polyanhydrides

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

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