Polymeric nanoparticles for protein kinase activity

Jong Ho Kim; Seulki Lee; Kwangmeyung Kim; Hyesung Jeon; Rang Woon Park; In San Kim; Kuiwon Choi; Ick Chan Kwon

doi:10.1039/b612773h

Polymeric nanoparticles for protein kinase activity

Jong Ho Kim, Seulki Lee, Kwangmeyung Kim, Hyesung Jeon, Rang Woon Park, In San Kim, Kuiwon Choi, Ick Chan Kwon

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Nanoparticles were prepared from poly-ion complexes, possessing both PEI-FITC-(PKA-specific substrate) (kemptide) and PAA-TRITC, which produce intermolecular FRET; the nanoparticles were dissociated by phosphorylation, presented a strong FITC intensity and can be applied to high-throughput screening for large chemical libraries, for drug discovery of kinase inhibitors.

Original language	English (US)
Pages (from-to)	1346-1348
Number of pages	3
Journal	Chemical Communications
Issue number	13
DOIs	https://doi.org/10.1039/b612773h
State	Published - 2007
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/b612773h

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title = "Polymeric nanoparticles for protein kinase activity",

abstract = "Nanoparticles were prepared from poly-ion complexes, possessing both PEI-FITC-(PKA-specific substrate) (kemptide) and PAA-TRITC, which produce intermolecular FRET; the nanoparticles were dissociated by phosphorylation, presented a strong FITC intensity and can be applied to high-throughput screening for large chemical libraries, for drug discovery of kinase inhibitors.",

author = "Kim, {Jong Ho} and Seulki Lee and Kwangmeyung Kim and Hyesung Jeon and Park, {Rang Woon} and Kim, {In San} and Kuiwon Choi and Kwon, {Ick Chan}",

year = "2007",

doi = "10.1039/b612773h",

language = "English (US)",

pages = "1346--1348",

journal = "Chemical Communications",

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publisher = "Royal Society of Chemistry",

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T1 - Polymeric nanoparticles for protein kinase activity

AU - Kim, Jong Ho

AU - Lee, Seulki

AU - Kim, Kwangmeyung

AU - Jeon, Hyesung

AU - Park, Rang Woon

AU - Kim, In San

AU - Choi, Kuiwon

AU - Kwon, Ick Chan

PY - 2007

Y1 - 2007

N2 - Nanoparticles were prepared from poly-ion complexes, possessing both PEI-FITC-(PKA-specific substrate) (kemptide) and PAA-TRITC, which produce intermolecular FRET; the nanoparticles were dissociated by phosphorylation, presented a strong FITC intensity and can be applied to high-throughput screening for large chemical libraries, for drug discovery of kinase inhibitors.

AB - Nanoparticles were prepared from poly-ion complexes, possessing both PEI-FITC-(PKA-specific substrate) (kemptide) and PAA-TRITC, which produce intermolecular FRET; the nanoparticles were dissociated by phosphorylation, presented a strong FITC intensity and can be applied to high-throughput screening for large chemical libraries, for drug discovery of kinase inhibitors.

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U2 - 10.1039/b612773h

DO - 10.1039/b612773h

M3 - Article

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SN - 1359-7345

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JO - Chemical Communications

JF - Chemical Communications

IS - 13

ER -

Polymeric nanoparticles for protein kinase activity

Abstract

ASJC Scopus subject areas

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