Polymeric materials for gene delivery and DNA vaccination

David N. Nguyen; Jordan J. Green; Juliana M. Chan; Robert Langer; Daniel G. Anderson

doi:10.1002/adma.200801478

Polymeric materials for gene delivery and DNA vaccination

David N. Nguyen, Jordan J. Green, Juliana M. Chan, Robert Langer, Daniel G. Anderson

Research output: Contribution to journal › Article › peer-review

201 Scopus citations

Abstract

Gene delivery holds great potential for the treatment of many different diseases. Vaccination with DNA holds particular promise, and may provide a solution to many technical challenges that hinder traditional vaccine systems including rapid development and production and induction of robust cell-mediated immune responses. However, few candidate DNA vaccines have progressed past preclinical development and none have been approved for human use. This Review focuses on the recent progress and challenges facing materials design for non viral DNA vaccine drug delivery systems. In particular, we highlight work on new polymeric materials and their effects on protective immune activation, gene delivery, and current efforts to optimize polymeric delivery systems for DNA vaccination.

Original language	English (US)
Pages (from-to)	847-867
Number of pages	21
Journal	Advanced Materials
Volume	21
Issue number	8
DOIs	https://doi.org/10.1002/adma.200801478
State	Published - Feb 23 2009
Externally published	Yes

ASJC Scopus subject areas

General Materials Science
Mechanics of Materials
Mechanical Engineering

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10.1002/adma.200801478

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AU - Langer, Robert

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Polymeric materials for gene delivery and DNA vaccination

Abstract

ASJC Scopus subject areas

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