Polymeric materials for gene delivery and DNA vaccination

David N. Nguyen, Jordan J. Green, Juliana M. Chan, Robert Langer, Daniel G. Anderson

Research output: Contribution to journalArticlepeer-review

Abstract

Gene delivery holds great potential for the treatment of many different diseases. Vaccination with DNA holds particular promise, and may provide a solution to many technical challenges that hinder traditional vaccine systems including rapid development and production and induction of robust cell-mediated immune responses. However, few candidate DNA vaccines have progressed past preclinical development and none have been approved for human use. This Review focuses on the recent progress and challenges facing materials design for non viral DNA vaccine drug delivery systems. In particular, we highlight work on new polymeric materials and their effects on protective immune activation, gene delivery, and current efforts to optimize polymeric delivery systems for DNA vaccination.

Original languageEnglish (US)
Pages (from-to)847-867
Number of pages21
JournalAdvanced Materials
Volume21
Issue number8
DOIs
StatePublished - Feb 23 2009
Externally publishedYes

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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