Polymer-supported reagents for methylphosphorylation and phosphorylation of carbohydrates

Keykavous Parang

Research output: Contribution to journalArticlepeer-review

Abstract

Two polymer-supported reagents for methylphosphorylation and phosphorylation of carbohydrates have been developed. p-Hydroxybenzyl alcohol and β-mercaptoethanol were immobilized on cross-linked divinylbenzene-polystyrene copolymer and conjugated with methyl N,N-diisopropylchlorophosphoramidite. Carbohydrates were reacted with polymer-bound phosphitylating reagents. Further oxidation, with or without the methoxy group deprotection, and cleavage yielded methylphosphorylated or phosphorylated carbohydrates, respectively.

Original languageEnglish (US)
Pages (from-to)1863-1866
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume12
Issue number14
DOIs
StatePublished - Jul 22 2002

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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