TY - JOUR
T1 - Polygenic and environmental influences on the course of African Americans' alcohol use from early adolescence through young adulthood
AU - Rabinowitz, Jill A.
AU - Musci, Rashelle J.
AU - Reboussin, Beth
AU - Milam, Adam J.
AU - Benke, Kelly S.
AU - Uhl, George R.
AU - Sisto, Danielle Y.
AU - Ialongo, Nicholas S.
AU - Maher, Brion S.
N1 - Publisher Copyright:
Copyright © 2019 Cambridge University Press.
PY - 2020/5/1
Y1 - 2020/5/1
N2 - The study examined (a) whether alcohol use subgroups could be identified among African Americans assessed from adolescence through early adulthood, and (b) whether subgroup membership was associated with the interaction between internalizing symptoms and antisocial behavior polygenic risk scores (PRSs) and environmental characteristics (i.e., parental monitoring, community disadvantage). Participants (N = 436) were initially recruited for an elementary school-based prevention trial in a Mid-Atlantic city. Youths reported on the frequency of their past year alcohol use from ages 14-26. DNA was obtained from participants at age 21. Internalizing symptoms and antisocial behavior PRSs were created based on a genome-wide association study (GWAS) conducted by Benke et al. (2014) and Tielbeek et al. (2017), respectively. Parental monitoring and community disadvantage were assessed at age 12. Four classes of past year alcohol use were identified: (a) early-onset, increasing; (b) late-onset, moderate use; (c) low steady; and (d) early-onset, decreasing. In high community disadvantaged settings, participants with a higher internalizing symptoms PRS were more likely to be in the early-onset, decreasing class than the low steady class. When exposed to elevated community disadvantage, participants with a higher antisocial behavior PRS were more likely to be in the early-onset, increasing class than the early-onset, decreasing and late-onset, moderate use classes.
AB - The study examined (a) whether alcohol use subgroups could be identified among African Americans assessed from adolescence through early adulthood, and (b) whether subgroup membership was associated with the interaction between internalizing symptoms and antisocial behavior polygenic risk scores (PRSs) and environmental characteristics (i.e., parental monitoring, community disadvantage). Participants (N = 436) were initially recruited for an elementary school-based prevention trial in a Mid-Atlantic city. Youths reported on the frequency of their past year alcohol use from ages 14-26. DNA was obtained from participants at age 21. Internalizing symptoms and antisocial behavior PRSs were created based on a genome-wide association study (GWAS) conducted by Benke et al. (2014) and Tielbeek et al. (2017), respectively. Parental monitoring and community disadvantage were assessed at age 12. Four classes of past year alcohol use were identified: (a) early-onset, increasing; (b) late-onset, moderate use; (c) low steady; and (d) early-onset, decreasing. In high community disadvantaged settings, participants with a higher internalizing symptoms PRS were more likely to be in the early-onset, decreasing class than the low steady class. When exposed to elevated community disadvantage, participants with a higher antisocial behavior PRS were more likely to be in the early-onset, increasing class than the early-onset, decreasing and late-onset, moderate use classes.
KW - alcohol use classes
KW - antisocial behavior polygenic risk score
KW - community disadvantage
KW - internalizing symptoms polygenic risk score
KW - parental monitoring
UR - http://www.scopus.com/inward/record.url?scp=85068386177&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85068386177&partnerID=8YFLogxK
U2 - 10.1017/S0954579419000701
DO - 10.1017/S0954579419000701
M3 - Article
C2 - 31256767
AN - SCOPUS:85068386177
SN - 0954-5794
VL - 32
SP - 703
EP - 718
JO - Development and psychopathology
JF - Development and psychopathology
IS - 2
ER -