Polycystin-1 negatively regulates polycystin-2 expression via the aggresome/autophagosome pathway

Valeriu Cebotaru, Liudmila Cebotaru, Hyunho Kim, Marco Chiaravalli, Alessandra Boletta, Feng Qian, William B. Guggino

Research output: Contribution to journalArticle

Abstract

Background: PC1 and PC2 function as a complex, but their interrelations are not completely understood. Results: Expression of PC1 accelerates degradation of PC2. Conclusion: PC1 negatively regulates PC2 expression, presumptively by enhancing degradation via the aggresome/autophagosome pathway. Significance: Understanding how PC1 regulates PC2 within a critical range may help elucidate the pathogenesis of cyst formation.

Original languageEnglish (US)
Pages (from-to)6404-6414
Number of pages11
JournalJournal of Biological Chemistry
Volume289
Issue number10
DOIs
StatePublished - Mar 7 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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