Polycystic kidney disease, cilia, and planar polarity.

Luis F. Menezes, Gregory G. Germino

Research output: Contribution to journalArticle

Abstract

Cystic kidney diseases are characterized by dilated or cystic kidney tubular segments. Changes in planar cell polarity, flow sensing, and/or proliferation have been proposed to explain these disorders. Over the last few years, several groups have suggested that ciliary dysfunction is a central component of cyst formation. We review evidence for and against each of these models, stressing some of the inconsistencies that should be resolved if an accurate understanding of cyst formation is to be achieved. We also comment on data supporting a model in which ciliary function could play different roles at different developmental stages and on the relevance of dissecting potential differences between pathways required for tubule formation and/or maintenance. 2009 Elsevier Inc. All rights reserved.

Original languageEnglish (US)
Pages (from-to)273-297
Number of pages25
JournalMethods in Cell Biology
Volume94
DOIs
StatePublished - 2009
Externally publishedYes

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Cystic Kidney Diseases
Polycystic Kidney Diseases
Cilia
Cysts
Cell Polarity
Maintenance

ASJC Scopus subject areas

  • Cell Biology

Cite this

Polycystic kidney disease, cilia, and planar polarity. / Menezes, Luis F.; Germino, Gregory G.

In: Methods in Cell Biology, Vol. 94, 2009, p. 273-297.

Research output: Contribution to journalArticle

Menezes, Luis F. ; Germino, Gregory G. / Polycystic kidney disease, cilia, and planar polarity. In: Methods in Cell Biology. 2009 ; Vol. 94. pp. 273-297.
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