Poly(AT) polymorphism in DNA repair gene XPC and lung cancer risk

Yong gang Wang, Deyin Xing, Wen Tan, Liang jun Wang, Ping zhang Tang, Dong xin Lin

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: It has been shown that suboptimal DNA repair capacity is associated with cancer risk and that a poly(AT) polymorphism in XPC gene (XPC PAT) may influence DNA capacity. This study was designed to assess the relationship between XPC PAT polymorphism and susceptibility to lung cancer in the Chinese population. METHODS: XPC genotypes were determined by PCR methods in 509 healthy controls and 597 patients with lung cancer. The adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using multivariate logistic regression model. RESULTS: Genotype frequencies of XPC PAT among controls were 37.9% (PAT-/-), 49.7% (PAT+/-) and 12.4% (PAT+/+), respectively. They were not significantly different from those among lung cancer patients (42.1%, 46.7% and 11.2%, respectively; P = 0.37). Individuals carrying XPC PAT+/+ genotype were not at increased risk for lung cancer as compared with those with PAT+/- or PAT-/- genotype (adjusted OR, 0.8; 95% CI, 0.55 approximately 1.16). No interaction between XPC genotype and smoking was observed. CONCLUSION: Our findings indicate that the XPC PAT polymorphism may not be associated with risk of lung cancer in the Chinese population.

Original languageEnglish (US)
Pages (from-to)555-557
Number of pages3
JournalZhonghua zhong liu za zhi [Chinese journal of oncology]
Volume25
Issue number6
StatePublished - Nov 2003
Externally publishedYes

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DNA Repair
Lung Neoplasms
Genotype
Genes
Logistic Models
Odds Ratio
Confidence Intervals
Population
Smoking
Polymerase Chain Reaction
DNA
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)
  • Oncology

Cite this

Wang, Y. G., Xing, D., Tan, W., Wang, L. J., Tang, P. Z., & Lin, D. X. (2003). Poly(AT) polymorphism in DNA repair gene XPC and lung cancer risk. Zhonghua zhong liu za zhi [Chinese journal of oncology], 25(6), 555-557.

Poly(AT) polymorphism in DNA repair gene XPC and lung cancer risk. / Wang, Yong gang; Xing, Deyin; Tan, Wen; Wang, Liang jun; Tang, Ping zhang; Lin, Dong xin.

In: Zhonghua zhong liu za zhi [Chinese journal of oncology], Vol. 25, No. 6, 11.2003, p. 555-557.

Research output: Contribution to journalArticle

Wang, YG, Xing, D, Tan, W, Wang, LJ, Tang, PZ & Lin, DX 2003, 'Poly(AT) polymorphism in DNA repair gene XPC and lung cancer risk', Zhonghua zhong liu za zhi [Chinese journal of oncology], vol. 25, no. 6, pp. 555-557.
Wang, Yong gang ; Xing, Deyin ; Tan, Wen ; Wang, Liang jun ; Tang, Ping zhang ; Lin, Dong xin. / Poly(AT) polymorphism in DNA repair gene XPC and lung cancer risk. In: Zhonghua zhong liu za zhi [Chinese journal of oncology]. 2003 ; Vol. 25, No. 6. pp. 555-557.
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abstract = "OBJECTIVE: It has been shown that suboptimal DNA repair capacity is associated with cancer risk and that a poly(AT) polymorphism in XPC gene (XPC PAT) may influence DNA capacity. This study was designed to assess the relationship between XPC PAT polymorphism and susceptibility to lung cancer in the Chinese population. METHODS: XPC genotypes were determined by PCR methods in 509 healthy controls and 597 patients with lung cancer. The adjusted odds ratios (ORs) and 95{\%} confidence intervals (CIs) were calculated using multivariate logistic regression model. RESULTS: Genotype frequencies of XPC PAT among controls were 37.9{\%} (PAT-/-), 49.7{\%} (PAT+/-) and 12.4{\%} (PAT+/+), respectively. They were not significantly different from those among lung cancer patients (42.1{\%}, 46.7{\%} and 11.2{\%}, respectively; P = 0.37). Individuals carrying XPC PAT+/+ genotype were not at increased risk for lung cancer as compared with those with PAT+/- or PAT-/- genotype (adjusted OR, 0.8; 95{\%} CI, 0.55 approximately 1.16). No interaction between XPC genotype and smoking was observed. CONCLUSION: Our findings indicate that the XPC PAT polymorphism may not be associated with risk of lung cancer in the Chinese population.",
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AU - Tan, Wen

AU - Wang, Liang jun

AU - Tang, Ping zhang

AU - Lin, Dong xin

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N2 - OBJECTIVE: It has been shown that suboptimal DNA repair capacity is associated with cancer risk and that a poly(AT) polymorphism in XPC gene (XPC PAT) may influence DNA capacity. This study was designed to assess the relationship between XPC PAT polymorphism and susceptibility to lung cancer in the Chinese population. METHODS: XPC genotypes were determined by PCR methods in 509 healthy controls and 597 patients with lung cancer. The adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using multivariate logistic regression model. RESULTS: Genotype frequencies of XPC PAT among controls were 37.9% (PAT-/-), 49.7% (PAT+/-) and 12.4% (PAT+/+), respectively. They were not significantly different from those among lung cancer patients (42.1%, 46.7% and 11.2%, respectively; P = 0.37). Individuals carrying XPC PAT+/+ genotype were not at increased risk for lung cancer as compared with those with PAT+/- or PAT-/- genotype (adjusted OR, 0.8; 95% CI, 0.55 approximately 1.16). No interaction between XPC genotype and smoking was observed. CONCLUSION: Our findings indicate that the XPC PAT polymorphism may not be associated with risk of lung cancer in the Chinese population.

AB - OBJECTIVE: It has been shown that suboptimal DNA repair capacity is associated with cancer risk and that a poly(AT) polymorphism in XPC gene (XPC PAT) may influence DNA capacity. This study was designed to assess the relationship between XPC PAT polymorphism and susceptibility to lung cancer in the Chinese population. METHODS: XPC genotypes were determined by PCR methods in 509 healthy controls and 597 patients with lung cancer. The adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using multivariate logistic regression model. RESULTS: Genotype frequencies of XPC PAT among controls were 37.9% (PAT-/-), 49.7% (PAT+/-) and 12.4% (PAT+/+), respectively. They were not significantly different from those among lung cancer patients (42.1%, 46.7% and 11.2%, respectively; P = 0.37). Individuals carrying XPC PAT+/+ genotype were not at increased risk for lung cancer as compared with those with PAT+/- or PAT-/- genotype (adjusted OR, 0.8; 95% CI, 0.55 approximately 1.16). No interaction between XPC genotype and smoking was observed. CONCLUSION: Our findings indicate that the XPC PAT polymorphism may not be associated with risk of lung cancer in the Chinese population.

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