TY - JOUR
T1 - POLYAMINES
T2 - DEVELOPMENTAL ALTERATIONS IN REGIONAL DISPOSITION AND METABOLISM IN RAT BRAIN
AU - Shaskan, E. G.
AU - Haraszti, J. H.
AU - Snyder, S. H.
PY - 1973/5
Y1 - 1973/5
N2 - The polyamines spermidine and spermine and the activity of the polyamine synthesizing enzyme, S‐adenosyl‐L‐methionine (SAM) decarboxylase, were measured in regions of adult rat brains and during postnatal development. In the adult, although spermidine levels tended to correlate with the relative amounts of white matter in some areas, there were striking exceptions. SAM decarboxylase activity of the adult brain was higher than in most other mammalian tissues, although brain levels of polyamines were among the lowest. SAM decarboxylase activity appeared to be localized to cellular cytoplasm. Its activity increased with age in contrast to the levels of spermine, spermidine, DNA and RNA which decreased during postnatal development.
AB - The polyamines spermidine and spermine and the activity of the polyamine synthesizing enzyme, S‐adenosyl‐L‐methionine (SAM) decarboxylase, were measured in regions of adult rat brains and during postnatal development. In the adult, although spermidine levels tended to correlate with the relative amounts of white matter in some areas, there were striking exceptions. SAM decarboxylase activity of the adult brain was higher than in most other mammalian tissues, although brain levels of polyamines were among the lowest. SAM decarboxylase activity appeared to be localized to cellular cytoplasm. Its activity increased with age in contrast to the levels of spermine, spermidine, DNA and RNA which decreased during postnatal development.
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U2 - 10.1111/j.1471-4159.1973.tb00256.x
DO - 10.1111/j.1471-4159.1973.tb00256.x
M3 - Article
C2 - 4716836
AN - SCOPUS:0015623972
SN - 0022-3042
VL - 20
SP - 1443
EP - 1452
JO - Journal of Neurochemistry
JF - Journal of Neurochemistry
IS - 5
ER -