Poly(ADP-ribose) regulates post-transcriptional gene regulation in the cytoplasm

Anthony K.L. Leung, Tanya Todorova, Yoshinari Ando, Paul Chang

Research output: Contribution to journalReview articlepeer-review

44 Scopus citations


Since its discovery in 1963, poly(ADP-ribose) (pADPr) has been shown to play important functions in the nucleus of multicellular eukaryotes. Each of these functions centers upon DNA metabolism, including DNA-damage repair, chromatin remodeling, transcription and telomere functions. We recently described two novel functions for pADPr in the cytoplasm, both of which involve RNA metabolism - (1) the assembly of cytoplasmic stress granules, cellular macrostructures that aggregate translationally stalled mRNA/protein complexes and (2) modulation of microRNA activities. Multiple stress granule-localized, post-transcriptional gene regulators, including microRNA-binding argonaute family members, are substrates for pADPr modification and are increasingly modified by pADPr upon stress. Interestingly, the cytoplasmic RNA regulatory functions for PARPs are likely mediated through activities of catalytically inactive PARP-13/ARTD13/ZC3HAV1/ZAP and mono/poly(ADP-ribose)-synthesizing enzymes, including PARP-5a/ARTD5/TNKS1, PARP-12/ARTD12/ZC3HDC1 and PARP-15/ARTD7/BAL3. These data are consistent with other recent work, which suggests that mono(ADP-ribosyl)ated residues can be poly(ADP-ribosyl)ated by different enzymes.

Original languageEnglish (US)
Pages (from-to)542-548
Number of pages7
JournalRNA Biology
Issue number5
StatePublished - May 2012


  • PARG
  • PARP
  • PARP-13
  • Stress
  • Stress granule
  • ZAP
  • microRNA

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


Dive into the research topics of 'Poly(ADP-ribose) regulates post-transcriptional gene regulation in the cytoplasm'. Together they form a unique fingerprint.

Cite this